Effects of sleep deprivation on leptin and ghrelin

What are the effects of sleep deprivation on leptin (“satiety hormone”) and ghrelin (“hunger hormone”)?

With sleep deprivation, leptin decreases and ghrelin (from the original root ghre meaning “to grow”) increases. In longer than average sleep, leptin increases, and ghrelin decreases. It has been documented that leptin secretion is blunted in sleep-deprived subjects and that over a 6-month period of time sleep deprived subjects gain an average of 10 lb more compared with rested subjects.


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