Do any markers help predict if an Rheumatoid Arthritis patient will have severe disease and a poor prognosis

Do any markers help predict if an Rheumatoid Arthritis patient will have severe disease and a poor prognosis?

Long disease duration prior to treatment, RF and ACPA positivity, and poor functional status (health assessment questionnaire score >1) at presentation are the best predictors of subsequent disability and joint damage. Other factors include:

• Generalized polyarthritis involving both small and large joints (>13 total joints)

• Extraarticular disease, especially nodules and vasculitis

• Persistently elevated ESR or CRP

• ANA positivity (if also RF-positive)

• Radiographic erosions within 2 years of disease onset

• HLA-DR4 genetic marker

• Low education level.

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