What is the difference between an autoinflammatory disease and an autoimmune disease?
Autoinflammatory diseases (e.g., Familial Mediterranean fever: Familial Autoinflammatory Syndromes) are diseases that have a chronic inflammatory response due to a defect in a component or regulation of the innate immune system. Autoimmune diseases (e.g., SLE) typically involve self-reactive CD4+ T lymphocytes and abnormalities in regulation of the adaptive immune system.
