Common extrarenal manifestations associated with kidney diseases

What are the common extrarenal manifestations associated with kidney diseases?

Arthritis and/or Musculoskeletal Symptoms

• Lupus nephritis

• Rheumatoid arthritis

• Henoch-Schönlein purpura

• Cryoglobulinemia

• Sarcoidosis

• Amyloidosis

• Multiple myeloma

• Gouty nephropathy

Hemoptysis

• Acute kidney injury with community acquired pneumonia

• Pulmonary renal syndrome

Goodpasture syndrome (also called anti-GBM disease)

Henoch-Schönlein purpura and immunoglobulin A nephropathy

Anti-Neutrophil Cytoplasmic Antibody (ANCA)-related vasculitides: Granulomatosis with polyangiitis (previously called Wegener granulomatosis); eosinophilic granulomatosis with polyangiitis (previously called Churg-Strauss syndrome); microscopic polyangiitis; and pauci-immune crescentic glomerulonephritis

Cryoglobulinemia

• Lupus nephritis with pneumonitis

• Pulmonary thromboembolism/infarction related to hypercoagulability (membranous nephropathy and antiphospholipid syndrome)

• Volume overload (congestive heart failure, mitral stenosis)

Hearing loss

• Hearing loss from aminoglycosides or loop diuretics in someone with kidney disease

• Alport syndrome

• Charcot-Marie-Tooth syndrome

• HDR syndrome (hypoparathyroidism, sensorineural hearing loss, and kidney disease; also called Barakat syndrome)

• Wolfram syndrome (diabetes insipidus, diabetes mellitus, optic atrophy)

• Bartter syndrome (type IV)

Abdominal discomfort

• Henoch-Schönlein purpura

• Cryoglobulinemia

• Microscopic polyangiitis

• ADPKD

Cervicocranial aneurysms:

• ADPKD (also with mitral valve prolapse)

• Fibromuscular dysplasia

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