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Common clinical features of cryoglobulinemia
Hyperviscosity syndrome (bleeding, vision changes, neurologic symptoms, etc.) is the most common manifestation in type I.
In MC, cutaneous manifestations are the most common, with arthralgias and neuropathy being other frequent findings.
The frequency of manifestations varies between studies, reflecting the characteristics of the patient populations.
Common Clinical Manifestations in cryoglobulinemia
| Purpura | 55%–100% | Raynaud’s phenomenon | 5%–35% |
| Arthralgias | 45%–100% | Renal | 10%–40% |
| Weakness | 70%–100% | Sicca | 30%–50% |
| Meltzer’s triad a | 40%–80% | Gastrointestinal | 2%–6% |
| Neuropathy | 20%–80% | Pulmonary | <5% |
| Ulcers | 10% | Malignancy | 10%–15% |
| Arthritis | <10% | Endocrine (diabetes mellitus, hypothyroid, erectile dysfunction) |
a Meltzer’s triad = purpura + arthralgias + weakness/myalgias.
