Collagen composition in early versus late stages of wound healing

How does the wounds collagen composition compare between the early and late stages of wound healing?

Type I collagen is the most abundant type of collagen in normal dermis (approximately 80% to 90%). During the early stages of wound healing, fibroblasts actively produce type III collagen, which may account for 30% of the collagen in a healing wound. By week 2, type I collagen again becomes the principal collagen produced by fibroblasts. During remodeling, type III collagen is replaced by type I collagen to restore the normal dermal collagen composition.


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