What is the definition of a clinically significant polyp on CTC?
The size threshold for a clinically significant polyp on CTC is 6 mm or greater. This cutoff is based on large patient series which demonstrate that lesions less than 6 mm on CTC often represent hyperplastic polyps or normal mucosal skin tags. Hyperplastic polyps almost never undergo malignant degeneration and so there is minimal to no risk of cancer developing in these lesions. The majority of polyps less than 5 mm are adenomas that will not undergo the adenoma-carcinoma sequence.