Causes of Myasthenia Gravis

Causes of Myasthenia Gravis

  • 1. Myasthenia Gravis is caused by different sets of antibodies directed against the AChR and its associated functional proteins.
  • 2. The thymus plays a major role in the immunopathogenesis of Myasthenia Gravis, and its removal improves chances for remission and response to medical therapy.
  • 3. Diagnostic tests for Myasthenia Gravis include RNS, AChR antibody assays, the Tensilon test, and Single fiber electromyography.
  • 4. Fifteen percent of Myasthenia Gravis patients have a thymoma, and 10% of thymomas in Myasthenia Gravis patients are malignant; therefore, every Myasthenia Gravis patient requires CT or MRI of the chest.
  • 5. Single fiber electromyography has the greatest sensitivity of any test for Myasthenia Gravis (90% to 95%) and is particularly useful in mild or pure ocular cases when other assays are more likely to be negative or indeterminate.
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