Can plasmapheresis be used to remove toxic substances?
Plasmapheresis can be considered for the removal of protein-bound toxins that are not readily removed with dialysis or hemoperfusion. Plasmapheresis is effective in removing highly protein-bound toxins from the blood but not from other fluid compartments. Reports of the successful use of plasmapheresis in the treatment of various drug overdoses and poisonings are generally anecdotal. Amanita poisoning (mushrooms) is the most frequent clinical diagnosis where plasmapheresis has been utilized with success, perhaps showing decreased mortality, especially in children.