Can Acute Kidney Injury be prevented?
Unfortunately, other than good medical care with the avoidance of volume contraction, the prevention of hypotension and the avoidance of nephrotoxic agents, there are no specific interventions that have been reliably demonstrated to prevent the development of Acute Kidney Injury.
The best model is the prevention of contrast-induced nephropathy following the administration of iodinated contrast agents for angiography and computed tomography.
Although multiple agents, such N -acetylcysteine and sodium bicarbonate, have been evaluated, the efficacy of these agents beyond volume expansion with isotonic saline remains controversial
