Autoimmune diseases which affect the neuromuscular junction
What autoimmune diseases primarily affect the neuromuscular junction (NMJ)?
Myasthenia gravis (MG), in which most antibodies are directed against the AChR on the postsynaptic muscle membrane, and Lambert–Eaton myasthenic syndrome (LEMS), in which antibodies are directed against the voltage-gated calcium channel in the nerve terminal, primarily affect the NMJ.
