Are there other options for iron supplementation in HD patients?
Oral ferric citrate, a phosphate binder, has absorbable iron that has been shown to increase serum ferritin and TSAT and decrease IV iron requirements in HD patients. Unlike other oral iron supplements, ferric citrate is associated more with diarrhea than with constipation.
Sodium ferric pyrophosphate added to the hemodialysate solution can replace 5 to 7 mg iron per treatment, decreasing IV iron requirements by 48%. Dialysate sodium ferric pyrophosphate has a similar safety profile to placebo.
