Are goodpasture syndrome and goodpasture disease the same
Are there differences between goodpasture syndrome and Anti GBM glomerulonephritis (goodpasture disease)?
No. Although both disease entities result from circulating anti-GBM antibodies, Goodpasture syndrome describes a systemic disease with a clinical constellation of pulmonary hemorrhage, circulating anti-GBM antibodies, and glomerulonephritis.
Anti-GBM glomerulonephritis, or Goodpasture disease , is kidney-limited and describes a proliferative glomerulonephritis, which results from the deposition of anti-GBM antibodies.
Anti-GBM antibodies are the same in patients with Goodpasture syndrome and Goodpasture disease. Because alveolar basement membrane contains the epitope of type IV collagen that is recognized by anti-GBM antibodies, the variable presence of pulmonary disease seems to reflect whether alveolar basement membrane epitope is accessible to the circulating anti-GBM antibodies.
Alveolar injury from infections, smoking, toxins, or other underlying lung disease may predispose the lungs to the deposition of anti-GBM antibodies.