What are the advantages of CRRT in a septic patient with AKI?
The use of hemofiltration in CRRT techniques may have an immunomodulatory effect. Some of the inflammatory mediators are water-soluble cytokines (interleukin [IL]-6, IL-8, IL-1) and the tumor necrosis factor, and can be removed by convection according to their molecular weight and degree of plasma protein binding.
Membrane characteristics such as molecular weight cut-off, structure, and charge also affect the ability of a solute to be cleared by RRT either by convection or by absorption.
In spite of some encouraging results, the clinical benefit of conventional CRRT in sepsis has been disappointing.
Consequently, efforts have been made to improve the efficiency of soluble mediator removal by increasing the ultrafiltration rates and enlarging the pore size of the membranes.
