What is the most accurate creatinine based estimating equations?
Kidney Disease International Global Outcomes (KDIGO) Guideline on Chronic Kidney Disease currently recommends using the Chronic Kidney Disease Epidemiology (CKD-EPI) 2009 creatinine equation:
where x is 0.7 for females and 0.9 for males
where α is 0.329 for females and 0.411 for males
where min indicates the minimum of SCr/x or 1
where max indicates the maximum of SCr/x or 1
Several online calculators are also available that can easily compute estimated GFR (eGFR) values from creatinine ( http://ckdepi.org/equations/gfr-calculator/ ). The CKD-EPI equation estimates GFR from serum creatinine, age, sex, and race. It was developed in a cohort of 8254 subjects pooled together from 10 research studies and clinical populations with diverse characteristics, including people with and without kidney diseases, and across a range of GFRs (2 to 198 mL/min per 1.73 m 2 ) and ages (18 to 97 years).
The equation was validated in a separate cohort of 3896 people from 16 separate studies, GFR range (2 to 200 mL/min per 1.73 m 2 ) and age range (18 to 93 years).