Accurate creatinine based estimating equations

What is the most accurate creatinine based estimating equations?

Kidney Disease International Global Outcomes (KDIGO) Guideline on Chronic Kidney Disease currently recommends using the Chronic Kidney Disease Epidemiology (CKD-EPI) 2009 creatinine equation:

where x is 0.7 for females and 0.9 for males

where α is 0.329 for females and 0.411 for males

where min indicates the minimum of SCr/x or 1

where max indicates the maximum of SCr/x or 1

Several online calculators are also available that can easily compute estimated GFR (eGFR) values from creatinine ( http://ckdepi.org/equations/gfr-calculator/ ). The CKD-EPI equation estimates GFR from serum creatinine, age, sex, and race. It was developed in a cohort of 8254 subjects pooled together from 10 research studies and clinical populations with diverse characteristics, including people with and without kidney diseases, and across a range of GFRs (2 to 198 mL/min per 1.73 m 2 ) and ages (18 to 97 years).

The equation was validated in a separate cohort of 3896 people from 16 separate studies, GFR range (2 to 200 mL/min per 1.73 m 2 ) and age range (18 to 93 years).

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