Ziv Aflibercept

What is Ziv Aflibercept

Ziv aflibercept is a fully-humanized recombinant fusion protein that inhibits angiogenesis.

It acts as a soluble receptor to bind vascular endothelial growth factor (VEGF)-A, VEGF-B, and placental growth factors 1 and 2 which prevents other native receptors from binding.

Ziv aflibercept is indicated in combination with fluorouracil, leucovorin, and irinotecan (FOLFIRI) for the treatment of metastatic colorectal cancer that is resistant to or has progressed following an oxaliplatin-containing regimen.

Ziv aflibercept can adversely affect wound healing and should be avoided for at least 4 weeks prior to elective surgery, for 4 weeks after major surgery, and until wounds have adequately healed after any surgery; the safety of resuming ziv-aflibercept after the resolution of wound healing complications has not been established.

Brand Name

ZALTRAP

Indications & Dosage

  • colorectal cancer

Side Effects

  • abdominal pain
  • angina
  • anorexia
  • antibody formation
  • asthenia
  • bleeding
  • dehydration
  • diarrhea
  • dysphonia
  • dyspnea
  • elevated hepatic enzymes
  • enterocutaneous fistula
  • epistaxis
  • fatigue
  • gastrointestinal fistula
  • GI bleeding
  • GI perforation
  • headache
  • heart failure
  • hematuria
  • hemoptysis
  • hemorrhoids
  • hypertension
  • hypertensive crisis
  • impaired wound healing
  • infection
  • intracranial bleeding
  • leukoencephalopathy
  • leukopenia
  • nephrotic syndrome
  • neutropenia
  • osteonecrosis
  • palmar-plantar erythrodysesthesia (hand and foot syndrome)
  • pharyngitis
  • proteinuria
  • pulmonary embolism
  • rhinorrhea
  • skin hyperpigmentation
  • stomatitis
  • stroke
  • thrombocytopenia
  • thromboembolism
  • thrombosis
  • vaginal fistula
  • weight loss

Monitoring Parameters

  • blood pressure
  • CBC with differential
  • pregnancy testing
  • urinalysis

Contraindications

  • bleeding
  • breast-feeding
  • contraception requirements
  • dental work
  • encephalopathy
  • geriatric
  • GI bleeding
  • GI perforation
  • hypertension
  • impaired wound healing
  • infection
  • infertility
  • intracranial bleeding
  • neutropenia
  • pregnancy
  • pregnancy testing
  • proteinuria
  • reproductive risk
  • surgery

Interactions

  • Clozapine
  • Palifermin
  • Penicillamine
  • Tuberculin Purified Protein Derivative, PPD