What factors contribute to a patients risk of opioid induced respiratory depression?
The RIOSORD analysis that is mentioned in the previous question is helpful in assessing risk for OIRD. The RIOSORD score is intended to determine probability of an overdose of serious opioid-induced respiratory depression. Each variable contributes a certain percentage to the score, and each RIOSORD score correlates with an average predicted probability of an opiate overdose or serious opioid-induced respiratory depression.
Civilian RIOSORD score factors include history of substance abuse disorder, diagnosis of bipolar or schizophrenia, stroke or cerebrovascular disease, heart failure, chronic kidney disease, nonmalignant pancreatic disease, chronic pulmonary disease, chronic headache, fentanyl, morphine, methadone, hydromorphone, ER/LA formulation of opioid, benzodiazepine, antidepressant, or daily morphine equivalence >100 mg/day.
Veterans RIOSORD score factors include opioid dependence, chronic hepatitis or cirrhosis, diagnosis of bipolar or schizophrenia, chronic kidney disease, chronic pulmonary disease, sleep apnea, active traumatic injury (excluding burns), morphine equivalents per day, ED visit in the past 6 months, hospital admission in the past 6 months.
