Vasopressin ADH

What is Vasopressin ADH

Vasopressin is a parenteral exogenous antidiuretic hormone (ADH) of the posterior pituitary gland indicated for diabetes insipidus, gastrointestinal radiography to dispel interfering gas shadows, prevention and treatment of postoperative abdominal distention, as well as to increase blood pressure in patients with vasodilatory shock who remain hypotensive despite fluids and catecholamines.

Endogenous ADH is a hormone secreted by the hypothalamus and stored in the posterior pituitary gland.

Commercial preparations of vasopressin exert the same pharmacologic effects as endogenous vasopressin.

Desmopressin (DDAVP) has a longer duration of action than vasopressin and a more favorable adverse effect profile and has replaced vasopressin as the drug of choice for central diabetes insipidus. DDAVP causes less stimulation of smooth muscle than vasopressin.

Brand Names

  • Pitressin
  • Vasostrict

Indications

  1. cardiac arrest
  2. cardiopulmonary resuscitation
  3. diabetes insipidus
  4. gastrointestinal radiography
  5. hypotension
  6. ileus
  7. post-cardiotomy shock
  8. pulseless electrical activity
  9. septic shock
  10. upper GI bleeding
  11. variceal bleeding
  12. ventricular asystole

Side Effects

  1. abdominal pain
  2. anaphylactic shock
  3. angina
  4. atrial fibrillation
  5. bleeding
  6. bradycardia
  7. cardiac arrest
  8. diabetes insipidus
  9. flatulence
  10. heart failure
  11. hyperbilirubinemia
  12. hyperhidrosis
  13. hyponatremia
  14. myocardial infarction
  15. nausea
  16. pallor
  17. peripheral vasoconstriction
  18. tremor
  19. urticaria
  20. vertigo
  21. vomiting
  22. water intoxication

Monitoring Parameters

  • blood pressure
  • heart rate
  • serum electrolytes
  • serum osmolality
  • serum sodium
  • weight

Contraindications

  • asthma
  • breast-feeding
  • coronary artery disease
  • heart failure
  • migraine
  • pregnancy
  • renal disease
  • seizure disorder

Interactions

  • Amitriptyline
  • Amitriptyline; Chlordiazepoxide
  • Articaine; Epinephrine
  • Carbamazepine
  • Chlorpropamide
  • Citalopram
  • Clomipramine
  • Clozapine
  • Corticorelin, Ovine
  • Cyclophosphamide
  • Demeclocycline
  • Desipramine
  • Desmopressin
  • Dopamine
  • Doxepin
  • Enalapril, Enalaprilat
  • Enalapril; Felodipine
  • Enalapril; Hydrochlorothiazide, HCTZ
  • Epinephrine
  • Escitalopram
  • Felbamate
  • Fludrocortisone
  • Fluoxetine
  • Fluoxetine; Olanzapine
  • Fluvoxamine
  • Foscarnet
  • Furosemide
  • Haloperidol
  • Heparin
  • Hydrochlorothiazide, HCTZ; Methyldopa
  • Ifosfamide
  • Imipramine
  • Indomethacin
  • Lithium
  • Mecamylamine
  • Methyldopa
  • Norepinephrine
  • Nortriptyline
  • Paroxetine
  • Pentamidine
  • Perphenazine; Amitriptyline
  • Prilocaine; Epinephrine
  • Protriptyline
  • Selective serotonin reuptake inhibitors
  • Sertraline
  • Tricyclic antidepressants
  • Trimipramine
  • Urea
  • Vincristine
  • Vincristine Liposomal
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