Hepatitis A Vaccine Inactivated Hepatitis B Vaccine Recombinant Brand Name– Twinrix
What is Twinrix
Twinrix is a bivalent vaccine containing the antigenic components of hepatitis A and hepatitis B vaccines.
It is considered an inactive vaccine.
The combination is used to confer immunity in adults at risk of hepatitis A virus (HAV) and hepatitis B virus (HBV).
The antibody responses to the bivalent vaccine have been statistically equivalent to the individual vaccines.
One month after the third dose of the bivalent vaccine, the seroconversion rate against hepatitis A was 99.9%, and the seroprotection rate against hepatitis B was 98.5%.
A pediatric formulation of Twinrix, containing half the antigenic components of the adult formulation is available in other countries but is not approved in the US.
Indications
- hepatitis A prophylaxis
- hepatitis B prophylaxis
Side Effects
- abdominal pain
- alopecia
- anaphylactic shock
- anaphylactoid reactions
- angioedema
- anorexia
- arthralgia
- back pain
- bronchospasm
- chills
- constipation
- diarrhea
- dizziness
- dysgeusia
- dyspnea
- ecchymosis
- encephalopathy
- erythema
- erythema multiforme
- erythema nodosum
- fatigue
- fever
- flushing
- Guillain-Barre syndrome
- headache
- hypertonia
- hypoesthesia
- injection site reaction
- insomnia
- irritability
- lymphadenopathy
- malaise
- migraine
- myalgia
- myelitis
- nausea
- neuritis
- optic neuritis
- paresthesias
- peripheral neuropathy
- photophobia
- purpura
- rash
- seizures
- serum sickness
- Stevens-Johnson syndrome
- syncope
- thrombocytopenia
- tinnitus
- urticaria
- vasculitis
- vertigo
- vomiting
- weakness
Monitoring Parameters
- hepatitis A serology
- hepatitis B serology
Contraindications
- anticoagulant therapy
- breast-feeding
- cardiac disease
- chemotherapy
- children
- coagulopathy
- fever
- geriatric
- hemophilia
- human immunodeficiency virus (HIV) infection
- immunosuppression
- infants
- infection
- intravenous administration
- laboratory test interference
- latex hypersensitivity
- neomycin hypersensitivity
- neonates
- pregnancy
- thrombocytopenia
- vitamin K deficiency
- yeast hypersensitivity
Interactions
- Hepatitis B Immune Globulin, HBIG
- Ocrelizumab
- Siponimod
