Triamcinolone

What is Triamcinolone

Triamcinolone is a synthetic glucocorticoid that is considered slightly more potent than prednisone when given orally.

Triamcinolone has little mineralocorticoid activity and is therefore not used systemically to manage adrenal insufficiency unless a more potent mineralocorticoid is administered concomitantly.

Triamcinolone is commercially available in nasal, parenteral, topical, and intravitreal injection formulations.

Oral and respiratory formulations of triamcinolone were previously available, but are no longer marketed in the U.S. Triamcinolone injections are commonly used for intra-articular use when such therapy is indicated.

The nasal spray is used to manage symptoms of seasonal and perennial allergies.

Topical preparations for corticosteroid-responsive dermatoses are considered to be of medium or high potency.

Side Effects

  1. abdominal pain
  2. acne vulgaris
  3. acneiform rash
  4. adrenocortical insufficiency
  5. alopecia
  6. amnesia
  7. anaphylactoid reactions
  8. angina
  9. angioedema
  10. anorexia
  11. anxiety
  12. appetite stimulation
  13. arachnoiditis
  14. arrhythmia exacerbation
  15. arthralgia
  16. arthropathy
  17. avascular necrosis
  18. blurred vision
  19. bone fractures
  20. bradycardia
  21. candidiasis
  22. cardiac arrest
  23. cardiomyopathy
  24. cataracts
  25. constipation
  26. contact dermatitis
  27. cough
  28. Cushing’s syndrome
  29. delirium
  30. depression
  31. diabetes mellitus
  32. diaphoresis
  33. diarrhea
  34. dysgeusia
  35. dyspepsia
  36. dysphonia
  37. ecchymosis
  38. edema
  39. EEG changes
  40. elevated hepatic enzymes
  41. emotional lability
  42. endophthalmitis
  43. epistaxis
  44. erythema
  45. esophageal ulceration
  46. euphoria
  47. exophthalmos
  48. fever
  49. fluid retention
  50. flushing
  51. folliculitis
  52. gastritis
  53. GI bleeding
  54. GI perforation
  55. glossitis
  56. glycosuria
  57. growth inhibition
  58. hallucinations
  59. heart failure
  60. hepatomegaly
  61. hiccups
  62. hoarseness
  63. hypercholesterolemia
  64. hyperglycemia
  65. hypernatremia
  66. hypertension
  67. hypertrichosis
  68. hypocalcemia
  69. hypokalemia
  70. hypotension
  71. hypothalamic-pituitary-adrenal (HPA) suppression
  72. immunosuppression
  73. impaired cognition
  74. impaired wound healing
  75. increased intracranial pressure
  76. infection
  77. influenza
  78. injection site reaction
  79. insomnia
  80. irritability
  81. lethargy
  82. leukocytosis
  83. lupus-like symptoms
  84. maculopapular rash
  85. malaise
  86. mania
  87. memory impairment
  88. meningitis
  89. menstrual irregularity
  90. metabolic alkalosis
  91. miliaria
  92. myalgia
  93. myasthenia
  94. myocardial infarction
  95. myopathy
  96. nasal dryness
  97. nasal irritation
  98. nasal septum perforation
  99. nausea
  100. neuritis
  101. ocular hemorrhage
  102. ocular hypertension
  103. ocular infection
  104. ocular inflammation
  105. optic neuritis
  106. osteopenia
  107. osteoporosis
  108. palpitations
  109. pancreatitis
  110. papilledema
  111. paresis
  112. paresthesias
  113. peptic ulcer
  114. perineal pain
  115. peripheral neuropathy
  116. petechiae
  117. pharyngitis
  118. phlebitis
  119. physiological dependence
  120. postmenopausal bleeding
  121. pruritus
  122. pseudotumor cerebri
  123. psychosis
  124. pulmonary edema
  125. purpura
  126. rash
  127. restlessness
  128. retinal detachment
  129. retinopathy
  130. seizures
  131. sinus tachycardia
  132. sinusitis
  133. skin atrophy
  134. skin hyperpigmentation
  135. skin hypopigmentation
  136. skin irritation
  137. skin ulcer
  138. sodium retention
  139. striae
  140. stroke
  141. syncope
  142. telangiectasia
  143. tendon rupture
  144. thromboembolism
  145. thrombosis
  146. tolerance
  147. urticaria
  148. vaginal bleeding
  149. vasculitis
  150. vertigo
  151. visual impairment
  152. vomiting
  153. weight gain
  154. weight loss
  155. withdrawal
  156. xerosis
  157. xerostomia

Monitoring Parameters

  • blood glucose
  • blood pressure
  • growth rate
  • intraocular pressure
  • ophthalmologic exam
  • pulmonary function tests (PFTs)
  • serum potassium
  • weight

Contraindications

  • abrupt discontinuation
  • acne rosacea
  • acne vulgaris
  • adrenal insufficiency
  • breast-feeding
  • cataracts
  • corticosteroid hypersensitivity
  • Cushing’s syndrome
  • diabetes mellitus
  • diverticulitis
  • ensure correct formulation selection
  • epidural administration
  • fungal infection
  • geriatric
  • GI perforation
  • glaucoma
  • growth inhibition
  • head trauma
  • heart failure
  • helminth infection
  • hepatic disease
  • herpes infection
  • hypertension
  • hyperthyroidism
  • hypothalamic-pituitary-adrenal (HPA) suppression
  • hypothyroidism
  • immune thrombocytopenic purpura (ITP)
  • immunosuppression
  • impaired wound healing
  • increased intracranial pressure
  • infection
  • intrathecal administration
  • intravenous administration
  • intravitreal administration
  • measles
  • myasthenia gravis
  • myocardial infarction
  • nasal septal perforation
  • nasal surgery
  • nasal trauma
  • neonates
  • neuromuscular disease
  • occlusive dressing
  • ocular exposure
  • ocular infection
  • osteopenia
  • osteoporosis
  • peptic ulcer disease
  • peripheral vascular disease
  • pregnancy
  • premature neonates
  • psychosis
  • renal disease
  • seizure disorder
  • skin abrasion
  • skin atrophy
  • surgery
  • thyroid disease
  • tuberculosis
  • ulcerative colitis
  • vaccination
  • varicella
  • viral infection

Interactions

  • Abatacept
  • Acetaminophen; Aspirin, ASA; Caffeine
  • Acetaminophen; Butalbital
  • Acetaminophen; Butalbital; Caffeine
  • Acetaminophen; Butalbital; Caffeine; Codeine
  • Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
  • Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
  • Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
  • Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
  • Acetaminophen; Dextromethorphan; Phenylephrine
  • Acetaminophen; Guaifenesin; Phenylephrine
  • Acetazolamide
  • Acetohexamide
  • Adalimumab
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  • Aldesleukin, IL-2
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  • Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
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  • Alogliptin; Metformin
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  • Amiloride; Hydrochlorothiazide, HCTZ
  • Aminolevulinic Acid
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  • Amiodarone
  • Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
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  • Amoxicillin; Clarithromycin; Lansoprazole
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  • Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
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  • Captopril; Hydrochlorothiazide, HCTZ
  • Carbamazepine
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  • Carbetapentane; Diphenhydramine; Phenylephrine
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  • Carbetapentane; Phenylephrine
  • Carbetapentane; Phenylephrine; Pyrilamine
  • Carbinoxamine; Hydrocodone; Phenylephrine
  • Carbinoxamine; Phenylephrine
  • Carmustine, BCNU
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  • Chlophedianol; Guaifenesin; Phenylephrine
  • Chlorambucil
  • Chloramphenicol
  • Chlorothiazide
  • Chlorpheniramine; Dextromethorphan; Phenylephrine
  • Chlorpheniramine; Dihydrocodeine; Phenylephrine
  • Chlorpheniramine; Hydrocodone; Phenylephrine
  • Chlorpheniramine; Phenylephrine
  • Chlorpropamide
  • Chlorthalidone
  • Chlorthalidone; Clonidine
  • Choline Salicylate; Magnesium Salicylate
  • Cimetidine
  • Cisatracurium
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  • Clindamycin
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  • Codeine; Phenylephrine; Promethazine
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  • Empagliflozin
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  • Enalapril; Hydrochlorothiazide, HCTZ
  • Ephedrine
  • Eprosartan; Hydrochlorothiazide, HCTZ
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  • Glyburide
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  • Glycerol Phenylbutyrate
  • grapefruit juice
  • Guaifenesin; Phenylephrine
  • Halofantrine
  • Haloperidol
  • Hemin
  • Heparin
  • Hetastarch
  • Hydantoins
  • Hydralazine; Hydrochlorothiazide, HCTZ
  • Hydrochlorothiazide, HCTZ
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  • Hydrochlorothiazide, HCTZ; Metoprolol
  • Hydrochlorothiazide, HCTZ; Moexipril
  • Hydrochlorothiazide, HCTZ; Olmesartan
  • Hydrochlorothiazide, HCTZ; Propranolol
  • Hydrochlorothiazide, HCTZ; Quinapril
  • Hydrochlorothiazide, HCTZ; Spironolactone
  • Hydrochlorothiazide, HCTZ; Telmisartan
  • Hydrochlorothiazide, HCTZ; Triamterene
  • Hydrochlorothiazide, HCTZ; Valsartan
  • Hydrocodone; Phenylephrine
  • Hydroxyurea
  • Hylan G-F 20
  • Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
  • Ibritumomab Tiuxetan
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  • Isoproterenol
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  • Methenamine; Sodium Acid Phosphate
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  • Potassium
  • Potassium Chloride
  • Potassium Phosphate; Sodium Phosphate
  • Potassium-sparing diuretics
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  • Sodium Benzoate; Sodium Phenylacetate
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