Timing of the daily dose of Glucocorticoids medication

Timing of the daily dose of Glucocorticoids medication to minimize the risk of HPA axis suppression

The body makes 10 to 12 mg/day of cortisol (equivalent to 2.5–3 mg/day prednisone).

Because natural cortisol secretion in humans has a circadian rhythm with the peak level in the morning, taking the GC at that time will have less of a suppressive effect on the release of cortisol-releasing factor and consequently less suppression of the HPA axis.

Additionally, the effect of GC is greater if taken in the morning because its clearance is 25% less.

However, when taking GCs long term, this probably is less important.

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