Terconazole

What is Terconazole

Terconazole is a triazole antifungal agent available for intravaginal use. It is structurally related to imidazole-derivative antifungal agents, although imidazoles have 2 nitrogens in the azole ring while terconazole and other triazoles have 3 nitrogens in the azole ring.

Terconazole is usually fungicidal against Candida albicans.

Although antifungal activity has been demonstrated against other fungi, it is indicated only for the treatment of vulvovaginal candidiasis. Terconazole was approved by the FDA in 1987.

Brand Names

• Terazol 3
• Terazol 7
• Zazole

Indications

• Candida albicans
• Candida sp.
• vulvovaginal candidiasis

Monitoring Parameters

• laboratory monitoring not necessary

Contraindications

• breast-feeding
• children
• contraceptive devices
• infants
• menstruation
• neonates
• ocular exposure
• ophthalmic administration
• pregnancy

Side Effects

1. abdominal pain
2. anaphylactoid reactions
3. arthralgia
4. asthenia
5. bronchospasm
6. chills
7. dizziness
8. dysmenorrhea
9. fever
10. headache
11. malaise
12. myalgia
13. nausea
14. photosensitivity
15. pruritus
16. rash
17. teratogenesis
18. toxic epidermal necrolysis
19. urticaria
20. vaginal irritation
21. vaginal pain
22. vomiting

Interactions

There are no drug interactions associated with Terconazole products.