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What is Talazoparib
Talazoparib is an oral poly (ADP-ribose) polymerase (PARP) inhibitor approved for the treatment of adult patients with deleterious or suspected deleterious germline BRCA-mutated (gBRCAm), HER2-negative locally advanced or metastatic breast cancer.
Treatment with talazoparib significantly improved progression-free survival compared with investigator’s choice of chemotherapy in an open-label clinical trial of patients with gBRCAm, HER2-negative locally advanced or metastatic breast cancer; 44% of patients in this trial had triple-negative breast cancer (TNBC); overall response rate and the duration of response were also improved in the talazoparib arm.
Twenty-five percent or more patients treated with talazoparib develop myelosuppression.
Monitor complete blood counts, as an interruption of therapy or dose reduction may be necessary.
Brand Name
TALZENNA
Indications
- breast cancer
For the treatment of deleterious or suspected deleterious germline BRCA-mutated (gBRCAm), HER2-negative locally advanced or metastatic breast cancer
Side Effects
- abdominal pain
- alopecia
- anemia
- anorexia
- asthenia
- bone marrow suppression
- diarrhea
- dizziness
- dysgeusia
- dyspepsia
- elevated hepatic enzymes
- fatigue
- headache
- hyperglycemia
- hypocalcemia
- leukemia
- leukopenia
- lymphopenia
- nausea
- neutropenia
- new primary malignancy
- stomatitis
- thrombocytopenia
- vomiting
Monitoring Parameters
- CBC with differential
- pregnancy testing
- serum creatinine
Contraindications
- anemia
- bone marrow suppression
- breast-feeding
- contraception requirements
- infertility
- leukemia
- leukopenia
- male-mediated teratogenicity
- myelodysplastic syndrome (MDS)
- neutropenia
- new primary malignancy
- pregnancy
- pregnancy testing
- reproductive risk
- thrombocytopenia
Interactions
- Acalabrutinib
- Amiodarone
- Amlodipine; Atorvastatin
- Amoxicillin; Clarithromycin; Lansoprazole
- Amoxicillin; Clarithromycin; Omeprazole
- Atazanavir; Cobicistat
- Atorvastatin
- Atorvastatin; Ezetimibe
- Azithromycin
- Brigatinib
- Cabozantinib
- Capmatinib
- Carvedilol
- Clarithromycin
- Cobicistat
- Conivaptan
- Cyclosporine
- Daclatasvir
- Darolutamide
- Darunavir; Cobicistat
- Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
- Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
- Dextromethorphan; Quinidine
- Diltiazem
- Dronedarone
- Elagolix
- Elagolix; Estradiol; Norethindrone acetate
- Elbasvir; Grazoprevir
- Elexacaftor; tezacaftor; ivacaftor
- Eliglustat
- Eltrombopag
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
- Enalapril; Felodipine
- Erythromycin
- Erythromycin; Sulfisoxazole
- Etravirine
- Felodipine
- Flibanserin
- Fluvoxamine
- Fostamatinib
- Glecaprevir; Pibrentasvir
- grapefruit juice
- Ibrutinib
- Isavuconazonium
- Istradefylline
- Itraconazole
- Ivacaftor
- Ketoconazole
- Lapatinib
- Ledipasvir; Sofosbuvir
- Leflunomide
- Lomitapide
- Lopinavir; Ritonavir
- Lumacaftor; Ivacaftor
- Lumacaftor; Ivacaftor
- Mefloquine
- Mifepristone
- Nelfinavir
- Neratinib
- Ombitasvir; Paritaprevir; Ritonavir
- Osimertinib
- Ponatinib
- Posaconazole
- Propafenone
- Quinidine
- Quinine
- Ranolazine
- Regorafenib
- Ritonavir
- Rolapitant
- Safinamide
- Sapropterin
- Saquinavir
- Sarecycline
- Sirolimus
- Sofosbuvir; Velpatasvir
- Sofosbuvir; Velpatasvir; Voxilaprevir
- Sorafenib
- Sulfasalazine
- Tacrolimus
- Tafamidis
- Tedizolid
- Telithromycin
- Temsirolimus
- Teriflunomide
- Tezacaftor; Ivacaftor
- Ticagrelor
- Trandolapril; Verapamil
- Tucatinib
- Vemurafenib
- Venetoclax
- Verapamil
- Zonisamide
