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Elvitegravir Cobicistat Emtricitabine Tenofovir Disoproxil Fumarate Brand Name-Stribild
What is Stribild
Stribild (Elvitegravir Cobicistat Emtricitabine Tenofovir Disoproxil Fumarate) is indicated for the treatment of human immunodeficiency virus (HIV) infection in antiretroviral-naive adults and pediatric patients 12 years of age and older weighing at least 35 kg.
The drug is also approved as a replacement therapy in treatment-experienced patients who have been virologically-suppressed (i.e., HIV RNA less than 50 copies/mL) on a stable antiretroviral regimen for at least 6 months, have no history of treatment failure, and who are without known substitutions associated with resistance to any of the individual components.
Stribild combines 4 medications (elvitegravir, an HIV integrase strand transfer inhibitor; cobicistat, a pharmacokinetic enhancer; emtricitabine, a nucleoside reverse transcriptase inhibitor or NRTI; tenofovir DF, an acyclic nucleotide reverse transcriptase inhibitor) into a single tablet that is administered once daily.
Another product, Genvoya, also contains elvitegravir, cobicistat, emtricitabine, and tenofovir; however, Genvoya contains a different tenofovir prodrug than Stribild.
Therefore, the two products are NOT interchangeable.
Elvitegravir Cobicistat Emtricitabine Tenofovir Disoproxil Fumarate constitutes a complete HIV treatment regimen; thus, administration with other antiretroviral medications is not recommended.
Approval for use in antiretroviral-naive patients was based on the results of two 144-week clinical trials. Data from these trials found the efficacy (HIV RNA less than 50 copies/mL) of Stribild (80% and 78%) to be comparable to efavirenz; emtricitabine; tenofovir DF (75%) and to atazanavir, ritonavir with emtricitabine; tenofovir DF (75%).
For use in treatment-experienced patients who are virologically-suppressed, approval was based on two 48-week trials comparing Stribild to regimens combining emtricitabine; tenofovir DF with either a protease inhibitor plus ritonavir or a non-nucleoside reverse transcriptase inhibitor.
After 48 weeks, 93% and 94% of Stribild recipients and 87% and 88% of patients in the active control groups maintained viral suppression (HIV RNA concentrations less than 50 copies/mL); virologic failures were reported in 1% of patients in each treatment arm.
Approval in pediatric patients was based on the results of a 48 week, single-group, open-label trial involving 50 treatment-naive pediatric patients (12 through 17 years) weighing at least 35 kg.
After receiving 48 weeks of treatment, 44 of the 50 drug recipients (88%) achieved HIV RNA concentrations less than 50 copies/mL, 4 patients had HIV RNA concentrations of 50 copies/mL or higher, 1 patient discontinued the study drug, and 1 patient was lost to follow-up.
Stribild contains two medications used for the treatment of chronic hepatitis B virus (HBV) infection (tenofovir DF and emtricitabine); however Stribild is not approved for this indication, nor is it indicated for the treatment of the patient coinfected with HBV and HIV.
The package labeling has a Black Box Warning that acute exacerbations of hepatitis B have been reported in patients after discontinuation of tenofovir DF and emtricitabine.
If treatment for HIV infection is discontinued in a patient coinfected with HBV, the patient should be closely monitored for several months for signs and symptoms of worsening hepatic function.
Indications
- human immunodeficiency virus (HIV)
- human immunodeficiency virus (HIV) infection
- human immunodeficiency virus (HIV) prophylaxis
NOTE: The HIV guidelines recommend consideration be given to avoiding use of tenofovir disoproxil fumarate-containing regimens in patients with renal disease and osteoporosis.
NOTE: HIV guidelines recommend all women of child-bearing potential undergo pregnancy testing prior to initiation of an elvitegravir-containing regimen.
Side Effects
- abdominal pain
- angioedema
- anxiety
- arthralgia
- asthenia
- back pain
- bone fractures
- bone pain
- cough
- depression
- diarrhea
- dizziness
- dyspepsia
- dyspnea
- elevated hepatic enzymes
- Fanconi syndrome
- fatigue
- fever
- flatulence
- glycosuria
- headache
- hematuria
- hepatic decompensation
- hepatic failure
- hepatitis B exacerbation
- hepatomegaly
- hyperamylasemia
- hyperbilirubinemia
- hypercholesterolemia
- hyperglycemia
- hyperlipidemia
- hypertriglyceridemia
- hypoglycemia
- hypokalemia
- hypophosphatemia
- infection
- insomnia
- lactic acidosis
- maculopapular rash
- myalgia
- myasthenia
- myopathy
- nausea
- neutropenia
- osteomalacia
- osteopenia
- pancreatitis
- paresthesias
- peripheral neuropathy
- pharyngitis
- proteinuria
- pruritus
- rash
- renal failure (unspecified)
- rhabdomyolysis
- rhinitis
- sinusitis
- skin discoloration
- skin hyperpigmentation
- steatosis
- suicidal ideation
- urticaria
- vomiting
- weight gain
Monitoring Parameters
- blood glucose
- CBC with differential
- CD4+ T cell count
- hepatitis B serology
- LFTs
- plasma hepatitis C RNA
- plasma HIV RNA
- pregnancy testing
- serum bilirubin (total and direct)
- serum cholesterol
- serum creatinine
- serum lipid profile
- serum phosphate
- urinalysis
Contraindications
- alcoholism
- autoimmune disease
- Black patients
- bone fractures
- breast-feeding
- children
- females
- Graves’ disease
- Guillain-Barre syndrome
- hepatic disease
- hepatitis B and HIV coinfection
- hepatitis B exacerbation
- hepatitis C and HIV coinfection
- hepatotoxicity or lactic acidosis
- Hispanic patients
- human immunodeficiency virus (HIV) infection resistance
- hypophosphatemia
- immune reconstitution syndrome
- obesity
- osteomalacia
- osteoporosis
- pregnancy
- renal disease
- renal failure
- renal impairment
Interactions
- Abacavir; Dolutegravir; Lamivudine
- Abacavir; Lamivudine, 3TC
- Abacavir; Lamivudine, 3TC; Zidovudine, ZDV
- Abemaciclib
- Acalabrutinib
- Acetaminophen; Aspirin, ASA; Caffeine
- Acetaminophen; Butalbital; Caffeine; Codeine
- Acetaminophen; Caffeine; Dihydrocodeine
- Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
- Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
- Acetaminophen; Codeine
- Acetaminophen; Dextromethorphan
- Acetaminophen; Dextromethorphan; Doxylamine
- Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
- Acetaminophen; Dextromethorphan; Phenylephrine
- Acetaminophen; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Diphenhydramine
- Acetaminophen; Hydrocodone
- Acetaminophen; Oxycodone
- Acetaminophen; Tramadol
- Acyclovir
- Adefovir
- Ado-Trastuzumab emtansine
- Afatinib
- Aldesleukin, IL-2
- Alfentanil
- Alfuzosin
- Aliskiren
- Aliskiren; Amlodipine
- Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
- Aliskiren; Hydrochlorothiazide, HCTZ
- Aliskiren; Valsartan
- Almotriptan
- Alogliptin; Metformin
- Alosetron
- Alpelisib
- Alprazolam
- Amikacin
- Aminoglycosides
- Aminosalicylate sodium, Aminosalicylic acid
- Amiodarone
- Amitriptyline
- Amitriptyline; Chlordiazepoxide
- Amlodipine
- Amlodipine; Atorvastatin
- Amlodipine; Benazepril
- Amlodipine; Celecoxib
- Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
- Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
- Amlodipine; Olmesartan
- Amlodipine; Telmisartan
- Amlodipine; Valsartan
- Amoxicillin; Clarithromycin; Lansoprazole
- Amoxicillin; Clarithromycin; Omeprazole
- Amphotericin B
- Amphotericin B cholesteryl sulfate complex (ABCD)
- Amphotericin B lipid complex (ABLC)
- Amphotericin B liposomal (LAmB)
- Antacids
- Apalutamide
- Apixaban
- Aprepitant, Fosaprepitant
- Aripiprazole
- Armodafinil
- Artemether; Lumefantrine
- Asenapine
- Aspirin, ASA
- Aspirin, ASA; Butalbital; Caffeine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Aspirin, ASA; Caffeine; Dihydrocodeine
- Aspirin, ASA; Caffeine; Orphenadrine
- Aspirin, ASA; Carisoprodol
- Aspirin, ASA; Carisoprodol; Codeine
- Aspirin, ASA; Citric Acid; Sodium Bicarbonate
- Aspirin, ASA; Dipyridamole
- Aspirin, ASA; Omeprazole
- Aspirin, ASA; Oxycodone
- Aspirin, ASA; Pravastatin
- Atazanavir
- Atazanavir; Cobicistat
- Atomoxetine
- Atorvastatin
- Atorvastatin; Ezetimibe
- Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
- Atropine; Hyoscyamine; Phenobarbital; Scopolamine
- Avanafil
- Avapritinib
- Axitinib
- Azelastine; Fluticasone
- Bacitracin
- Bedaquiline
- Belladonna Alkaloids; Ergotamine; Phenobarbital
- Benzhydrocodone; Acetaminophen
- Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
- Bepridil
- Betamethasone
- Betrixaban
- Bexarotene
- Bismuth Subsalicylate
- Bismuth Subsalicylate; Metronidazole; Tetracycline
- Boceprevir
- Bortezomib
- Bosentan
- Bosutinib
- Brentuximab vedotin
- Brexpiprazole
- Brigatinib
- Brimonidine; Timolol
- Bromocriptine
- Brompheniramine; Dextromethorphan; Guaifenesin
- Brompheniramine; Dextromethorphan; Phenylephrine
- Brompheniramine; Guaifenesin; Hydrocodone
- Brompheniramine; Hydrocodone; Pseudoephedrine
- Budesonide
- Budesonide; Formoterol
- Bupivacaine
- Bupivacaine Liposomal
- Bupivacaine; Lidocaine
- Buprenorphine
- Buprenorphine; Naloxone
- Bupropion
- Bupropion; Naltrexone
- Buspirone
- Cabazitaxel
- Cabozantinib
- Caffeine; Ergotamine
- Calcium Carbonate
- Calcium Carbonate; Magnesium Hydroxide
- Calcium Carbonate; Risedronate
- Calcium Carbonate; Simethicone
- Canagliflozin; Metformin
- Cannabidiol
- Capmatinib
- Carbamazepine
- Carbetapentane; Chlorpheniramine
- Carbetapentane; Chlorpheniramine; Phenylephrine
- Carbetapentane; Diphenhydramine; Phenylephrine
- Carbinoxamine; Dextromethorphan; Pseudoephedrine
- Carbinoxamine; Hydrocodone; Phenylephrine
- Carbinoxamine; Hydrocodone; Pseudoephedrine
- Carboplatin
- Cariprazine
- Carvedilol
- Celecoxib
- Cenobamate
- Ceritinib
- Cerivastatin
- Cevimeline
- Chloramphenicol
- Chlordiazepoxide
- Chlordiazepoxide; Clidinium
- Chlorpheniramine
- Chlorpheniramine; Codeine
- Chlorpheniramine; Dextromethorphan
- Chlorpheniramine; Dextromethorphan; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
- Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Hydrocodone
- Chlorpheniramine; Hydrocodone; Phenylephrine
- Chlorpheniramine; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Phenylephrine
- Chlorpheniramine; Pseudoephedrine
- Chlorpromazine
- Choline Salicylate; Magnesium Salicylate
- Ciclesonide
- Cidofovir
- Cilostazol
- Cimetidine
- Cinacalcet
- Cisapride
- Cisplatin
- Citalopram
- Clarithromycin
- Clindamycin
- Clobazam
- Clofarabine
- Clomipramine
- Clonazepam
- Clorazepate
- Clozapine
- Cobimetinib
- Cocaine
- Codeine
- Codeine; Guaifenesin
- Codeine; Phenylephrine; Promethazine
- Codeine; Promethazine
- Colchicine
- Colchicine; Probenecid
- Colistimethate, Colistin, Polymyxin E
- Conivaptan
- Conjugated Estrogens; Medroxyprogesterone
- Copanlisib
- Crizotinib
- Cyclosporine
- Dabigatran
- Dabrafenib
- Daclatasvir
- Danazol
- Dapagliflozin; Metformin
- Dapagliflozin; Saxagliptin
- Dapsone
- Darifenacin
- Darolutamide
- Darunavir
- Darunavir; Cobicistat
- Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
- Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
- Dasatinib
- Deflazacort
- Delavirdine
- Desipramine
- Desvenlafaxine
- Dexamethasone
- Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
- Dexlansoprazole
- Dextromethorphan
- Dextromethorphan; Diphenhydramine; Phenylephrine
- Dextromethorphan; Guaifenesin
- Dextromethorphan; Guaifenesin; Phenylephrine
- Dextromethorphan; Guaifenesin; Potassium Guaiacolsulfonate
- Dextromethorphan; Guaifenesin; Pseudoephedrine
- Dextromethorphan; Promethazine
- Dextromethorphan; Quinidine
- Diazepam
- Dichlorphenamide
- Diclofenac
- Diclofenac; Misoprostol
- Didanosine, ddI
- Dienogest; Estradiol valerate
- Diflunisal
- Digoxin
- Dihydrocodeine; Guaifenesin; Pseudoephedrine
- Dihydroergotamine
- Diltiazem
- Diphenhydramine
- Diphenhydramine; Hydrocodone; Phenylephrine
- Diphenhydramine; Ibuprofen
- Diphenhydramine; Naproxen
- Diphenhydramine; Phenylephrine
- Disopyramide
- Disulfiram
- Docetaxel
- Dofetilide
- Dolasetron
- Dolutegravir
- Dolutegravir; Lamivudine
- Dolutegravir; Rilpivirine
- Donepezil
- Donepezil; Memantine
- Doravirine
- Doravirine; Lamivudine; Tenofovir disoproxil fumarate
- Dorzolamide; Timolol
- Doxazosin
- Doxepin
- Doxorubicin
- Dronabinol
- Dronedarone
- Drospirenone
- Drospirenone; Estradiol
- Drospirenone; Ethinyl Estradiol
- Drospirenone; Ethinyl Estradiol; Levomefolate
- Duloxetine
- Dutasteride
- Dutasteride; Tamsulosin
- Duvelisib
- Echinacea
- Edoxaban
- Efavirenz
- Efavirenz; Emtricitabine; Tenofovir
- Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
- Elagolix
- Elagolix; Estradiol; Norethindrone acetate
- Elbasvir; Grazoprevir
- Eletriptan
- Elexacaftor; tezacaftor; ivacaftor
- Eliglustat
- Eluxadoline
- Empagliflozin; Linagliptin; Metformin
- Empagliflozin; Metformin
- Emtricitabine; Rilpivirine; Tenofovir alafenamide
- Emtricitabine; Rilpivirine; Tenofovir disoproxil fumarate
- Enalapril; Felodipine
- Encainide
- Encorafenib
- Enfortumab vedotin
- Entrectinib
- Enzalutamide
- Eplerenone
- Erdafitinib
- Ergotamine
- Erlotinib
- Ertugliflozin; Metformin
- Erythromycin
- Erythromycin; Sulfisoxazole
- Escitalopram
- Eslicarbazepine
- Esomeprazole
- Esomeprazole; Naproxen
- Estazolam
- Estradiol Cypionate; Medroxyprogesterone
- Estradiol; Levonorgestrel
- Estradiol; Norethindrone
- Estradiol; Norgestimate
- Estradiol; Progesterone
- Eszopiclone
- Ethinyl Estradiol
- Ethinyl Estradiol; Desogestrel
- Ethinyl Estradiol; Ethynodiol Diacetate
- Ethinyl Estradiol; Etonogestrel
- Ethinyl Estradiol; Levonorgestrel
- Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate
- Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
- Ethinyl Estradiol; Norelgestromin
- Ethinyl Estradiol; Norethindrone
- Ethinyl Estradiol; Norethindrone Acetate
- Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
- Ethinyl Estradiol; Norethindrone; Ferrous fumarate
- Ethinyl Estradiol; Norgestimate
- Ethinyl Estradiol; Norgestrel
- Ethosuximide
- Etodolac
- Etonogestrel
- Etravirine
- Everolimus
- Ezetimibe; Simvastatin
- Famotidine; Ibuprofen
- Fedratinib
- Felbamate
- Felodipine
- Fenoprofen
- Fentanyl
- Fexofenadine
- Fexofenadine; Pseudoephedrine
- Flecainide
- Flibanserin
- Fluconazole
- Fluoxetine
- Fluoxetine; Olanzapine
- Fluphenazine
- Flurazepam
- Flurbiprofen
- Flutamide
- Fluticasone
- Fluticasone; Salmeterol
- Fluticasone; Umeclidinium; Vilanterol
- Fluticasone; Vilanterol
- Fluvastatin
- Fluvoxamine
- food
- Formoterol; Mometasone
- Fosamprenavir
- Foscarnet
- Fosphenytoin
- Fostamatinib
- Ganciclovir
- Gefitinib
- Gentamicin
- Gilteritinib
- Glasdegib
- Glecaprevir; Pibrentasvir
- Glimepiride
- Glimepiride; Pioglitazone
- Glimepiride; Rosiglitazone
- Glipizide
- Glipizide; Metformin
- Glyburide
- Glyburide; Metformin
- Granisetron
- grapefruit juice
- Guaifenesin; Hydrocodone
- Guaifenesin; Hydrocodone; Pseudoephedrine
- Guanfacine
- Haloperidol
- Homatropine; Hydrocodone
- Hydrochlorothiazide, HCTZ; Losartan
- Hydrochlorothiazide, HCTZ; Metoprolol
- Hydrochlorothiazide, HCTZ; Propranolol
- Hydrochlorothiazide, HCTZ; Valsartan
- Hydrocodone
- Hydrocodone; Ibuprofen
- Hydrocodone; Phenylephrine
- Hydrocodone; Potassium Guaiacolsulfonate
- Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
- Hydrocodone; Pseudoephedrine
- Hydroxyprogesterone
- Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
- Ibrutinib
- Ibuprofen
- Ibuprofen; Oxycodone
- Ibuprofen; Pseudoephedrine
- Idelalisib
- Ifosfamide
- Iloperidone
- Imatinib
- Imipramine
- Indacaterol
- Indacaterol; Glycopyrrolate
- Indinavir
- Indomethacin
- Interferon Alfa-2b; Ribavirin
- Interferons
- Iohexol
- Iopamidol
- Iopromide
- Ioversol
- Irinotecan
- Irinotecan Liposomal
- Isavuconazonium
- Isoniazid, INH
- Isoniazid, INH; Pyrazinamide, PZA; Rifampin
- Isoniazid, INH; Rifampin
- Isosulfan Blue
- Isradipine
- Istradefylline
- Itraconazole
- Ivabradine
- Ivacaftor
- Ivosidenib
- Ixabepilone
- Kanamycin
- Ketoconazole
- Ketoprofen
- Ketorolac
- Lamivudine, 3TC
- Lamivudine, 3TC; Zidovudine, ZDV
- Lamivudine; Tenofovir Disoproxil Fumarate
- Lansoprazole
- Lansoprazole; Naproxen
- Lapatinib
- Larotrectinib
- Ledipasvir; Sofosbuvir
- Lefamulin
- Lemborexant
- Lesinurad
- Lesinurad; Allopurinol
- Letermovir
- Leuprolide; Norethindrone
- Levomilnacipran
- Levonorgestrel
- Lidocaine
- Lidocaine; Prilocaine
- Linagliptin; Metformin
- Lomitapide
- Loperamide
- Loperamide; Simethicone
- Lopinavir; Ritonavir
- Lorcaserin
- Lorlatinib
- Losartan
- Lovastatin
- Lovastatin; Niacin
- Lumacaftor; Ivacaftor
- Lumacaftor; Ivacaftor
- Lumateperone
- Lurasidone
- Lurbinectedin
- Macitentan
- Magnesium Salicylate
- Maprotiline
- Maraviroc
- Meclizine
- Meclofenamate Sodium
- Medroxyprogesterone
- Mefenamic Acid
- Mefloquine
- Meloxicam
- Meperidine; Promethazine
- Mestranol; Norethindrone
- Metformin
- Metformin; Pioglitazone
- Metformin; Repaglinide
- Metformin; Rosiglitazone
- Metformin; Saxagliptin
- Metformin; Sitagliptin
- Methadone
- Methamphetamine
- Methylergonovine
- Methylprednisolone
- Metoclopramide
- Metoprolol
- Mexiletine
- Midazolam
- Midostaurin
- Mifepristone
- Mirabegron
- Mirtazapine
- Mitomycin
- Mitotane
- Modafinil
- Mometasone
- Morphine
- Morphine; Naltrexone
- Nabumetone
- Nafcillin
- Naldemedine
- Naloxegol
- Naloxone
- Nanoparticle Albumin-Bound Paclitaxel
- Naproxen
- Naproxen; Pseudoephedrine
- Naproxen; Sumatriptan
- Nateglinide
- Nebivolol
- Nebivolol; Valsartan
- Nefazodone
- Nelfinavir
- Neratinib
- Netupitant, Fosnetupitant; Palonosetron
- Nevirapine
- Niacin; Simvastatin
- Nicardipine
- Nicotine
- Nifedipine
- Nilotinib
- Nimodipine
- Nintedanib
- Nisoldipine
- Non-Ionic Contrast Media
- Nonsteroidal antiinflammatory drugs
- Norethindrone
- Norgestrel
- Nortriptyline
- Octreotide
- Olanzapine
- Olaparib
- Ombitasvir; Paritaprevir; Ritonavir
- Omeprazole
- Omeprazole; Amoxicillin; Rifabutin
- Omeprazole; Sodium Bicarbonate
- Ondansetron
- Oral Contraceptives
- Oritavancin
- Orlistat
- Osilodrostat
- Osimertinib
- Ospemifene
- Oxaliplatin
- Oxaprozin
- Oxcarbazepine
- Oxybutynin
- Oxycodone
- Ozanimod
- Paclitaxel
- Palbociclib
- Palonosetron
- Pamidronate
- Panobinostat
- Paricalcitol
- Paromomycin
- Paroxetine
- Pazopanib
- Pemigatinib
- Pentamidine
- Pentazocine; Naloxone
- Perampanel
- Perindopril; Amlodipine
- Perphenazine
- Perphenazine; Amitriptyline
- Pexidartinib
- Phenobarbital
- Phentermine; Topiramate
- Phenylephrine; Promethazine
- Phenytoin
- Pimavanserin
- Pimozide
- Pirfenidone
- Piroxicam
- Pitavastatin
- Plazomicin
- Polatuzumab Vedotin
- Polymyxin B
- Polymyxins
- Ponatinib
- Posaconazole
- Pravastatin
- Prednisone
- Primidone
- Probenecid
- Progesterone
- Promethazine
- Propafenone
- Propranolol
- Protriptyline
- Quazepam
- Quetiapine
- Quinidine
- Quinine
- Rabeprazole
- Ramelteon
- Ranolazine
- Regorafenib
- Repaglinide
- Retapamulin
- Revefenacin
- Ribavirin
- Ribociclib
- Ribociclib; Letrozole
- Rifabutin
- Rifampin
- Rifapentine
- Rifaximin
- Rilpivirine
- Rimegepant
- Ripretinib
- Risperidone
- Ritonavir
- Rivaroxaban
- Rofecoxib
- Roflumilast
- Rolapitant
- Romidepsin
- Ropivacaine
- Rosiglitazone
- Rosuvastatin
- Ruxolitinib
- Sacubitril; Valsartan
- Salicylates
- Salmeterol
- Salsalate
- Sapropterin
- Saquinavir
- Saxagliptin
- Segesterone Acetate; Ethinyl Estradiol
- Selective serotonin reuptake inhibitors
- Selegiline
- Selpercatinib
- Selumetinib
- Sertraline
- Sibutramine
- Sildenafil
- Silodosin
- Simeprevir
- Simvastatin
- Simvastatin; Sitagliptin
- Siponimod
- Sirolimus
- Sodium Bicarbonate
- Sofosbuvir
- Sofosbuvir; Velpatasvir
- Sofosbuvir; Velpatasvir; Voxilaprevir
- Solifenacin
- Sonidegib
- Sorafenib
- St. John’s Wort, Hypericum perforatum
- Streptogramins
- Streptomycin
- Sufentanil
- Sulfamethoxazole; Trimethoprim, SMX-TMP, Cotrimoxazole
- Sulindac
- Sunitinib
- Suvorexant
- Tacrolimus
- Tadalafil
- Tafamidis
- Talazoparib
- Talimogene Laherparepvec
- Tamsulosin
- Tazemetostat
- Tedizolid
- Telaprevir
- Telithromycin
- Telotristat Ethyl
- Temsirolimus
- Teniposide
- Tenofovir Alafenamide
- Terbinafine
- Testosterone
- Tetrabenazine
- Tezacaftor; Ivacaftor
- Theophylline, Aminophylline
- Thioridazine
- Thiotepa
- Tiagabine
- Ticagrelor
- Timolol
- Tinidazole
- Tipranavir
- Tobramycin
- Tofacitinib
- Tolmetin
- Tolterodine
- Tolvaptan
- Topiramate
- Topotecan
- Toremifene
- Trabectedin
- Tramadol
- Trandolapril; Verapamil
- Trazodone
- Triamcinolone
- Triazolam
- Tricyclic antidepressants
- Trimipramine
- Trospium
- Tucatinib
- Ubrogepant
- Ulipristal
- Umeclidinium; Vilanterol
- Upadacitinib
- Valacyclovir
- Valbenazine
- Valdecoxib
- Valganciclovir
- Valproic Acid, Divalproex Sodium
- Valsartan
- Vancomycin
- Vardenafil
- Vemurafenib
- Venetoclax
- Venlafaxine
- Verapamil
- Vilazodone
- Vinblastine
- Vincristine
- Vincristine Liposomal
- Vinorelbine
- Vorapaxar
- Voriconazole
- Voxelotor
- Warfarin
- Yohimbine
- Zafirlukast
- Zaleplon
- Zanubrutinib
- Zileuton
- Ziprasidone
- Zoledronic Acid
- Zolmitriptan
- Zolpidem
- Zonisamide
