Sotalol

What is Sotalol

Sotalol is a hydrophilic, nonselective beta-adrenergic blocking agent, with low lipid-solubility. It is used to treat ventricular and supraventricular arrhythmias.

Indications & Dosage

• atrial fibrillation
• atrial fibrillation prophylaxis
• atrial flutter
• cardiac surgery
• junctional ectopic tachycardia
• paroxysmal atrial tachycardia
• paroxysmal supraventricular tachycardia (PSVT)
• supraventricular arrhythmias
• ventricular tachycardia
• Wolff-Parkinson-White (WPW) syndrome

Side Effects

1. abdominal pain
2. alopecia
3. arrhythmia exacerbation
4. asthenia
5. AV block
6. bradycardia
7. bronchospasm
8. chest pain (unspecified)
9. confusion
10. cough
11. depression
12. diabetes mellitus
13. diarrhea
14. dizziness
15. dyspnea
16. emotional lability
17. eosinophilia
18. fatigue
19. fever
20. headache
21. heart failure
22. hyperglycemia
23. hyperhidrosis
24. hyperlipidemia
25. hypoglycemia
26. hypotension
27. leukopenia
28. muscle paralysis
29. musculoskeletal pain
30. myalgia
31. nausea
32. palpitations
33. peripheral neuropathy
34. photosensitivity
35. pruritus
36. pulmonary edema
37. QT prolongation
38. thrombocytopenia
39. torsade de pointes
40. ventricular fibrillation
41. ventricular tachycardia
42. vertigo
43. visual impairment
44. vomiting
45. weakness
46. withdrawal

Monitoring Parameters

• ECG
• serum creatinine/BUN

Contraindications

• abrupt discontinuation
• acute bronchospasm
• acute myocardial infarction
• alcoholism
• asthma
• AV block
• bradycardia
• breast-feeding
• bronchitis
• cardiac arrhythmias
• cardiac disease
• cardiogenic shock
• chronic lung disease (CLD)
• coronary artery disease
• diabetes mellitus
• diarrhea
• females
• geriatric
• heart failure
• hepatic disease
• hypertension
• hyperthyroidism
• hypocalcemia
• hypokalemia
• hypomagnesemia
• infertility
• labor
• laboratory test interference
• long QT syndrome
• malnutrition
• myocardial infarction
• obstetric delivery
• peripheral vascular disease
• pregnancy
• QT prolongation
• Raynaud’s phenomenon
• renal failure
• renal impairment
• reproductive risk
• requires a specialized care setting
• requires an experienced clinician
• sick sinus syndrome
• surgery
• thyroid disease
• ventricular arrhythmias
• ventricular fibrillation
• ventricular tachycardia

Interactions

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