Propafenone

Propafenone Brand Names- Rythmol | Rythmol SR

What is Propafenone

Propafenone is an oral class IC antiarrhythmic agent which is used for the treatment of supraventricular arrhythmias and suppression of life-threatening ventricular arrhythmias.

Propafenone is similar mechanistically to encainide and flecainide, but is structurally similar to beta-blockers and possesses beta-blocking activity.

Propafenone is FDA-approved to treat symptomatic supraventricular arrhythmias or severe, life-threatening ventricular arrhythmias.

The IC antiarrhythmic agents have been shown to possess proarrhythmic characteristics during the CAST trials, which limits the use of these agents to prevent ventricular arrhythmias.

Propafenone is useful in pharmacologically convert atrial fibrillation to sinus rhythm, and to maintain sinus rhythm.

Propafenone therapy should be initiated in the hospital to allow for appropriate electrocardiographic (ECG) monitoring. Rythmol® (propafenone) was approved by the FDA in November 1989. Generic propafenone tablets became available in October 2000. Extended-release capsules (Rythmol® SR) were approved in September 2003.

Indications

1. atrial fibrillation
2. atrial flutter
3. paroxysmal supraventricular tachycardia (PSVT) prophylaxis
4. supraventricular arrhythmias
5. ventricular tachycardia
6. Wolff-Parkinson-White (WPW) syndrome

For the treatment of sustained ventricular tachycardia that is deemed to be life-threatening

Side Effects

1. abdominal pain
2. agranulocytosis
3. alopecia
4. amnesia
5. anemia
6. angina
7. anorexia
8. anxiety
9. apnea
10. arrhythmia exacerbation
11. asystole
12. ataxia
13. atrial flutter
14. AV block
15. blurred vision
16. bradycardia
17. bundle-branch block
18. cardiac arrest
19. chest pain (unspecified)
20. cholestasis
21. coma
22. confusion
23. constipation
24. cough
25. dehydration
26. depression
27. diabetes mellitus
28. diarrhea
29. dizziness
30. drowsiness
31. dysgeusia
32. dyspepsia
33. dysphagia
34. dyspnea
35. dysuria
36. ecchymosis
37. edema
38. elevated hepatic enzymes
39. emotional lability
40. epistaxis
41. eructation
42. erythema
43. fatigue
44. fever
45. flatulence
46. flushing
47. gastroesophageal reflux
48. GI obstruction
49. glossitis
50. glycosuria
51. gout
52. halitosis
53. headache
54. heart failure
55. hematoma
56. hematuria
57. hemoptysis
58. hepatitis
59. hepatomegaly
60. hot flashes
61. hypercholesterolemia
62. hyperglycemia
63. hyperhidrosis
64. hyperlipidemia
65. hypertension
66. hypertensive crisis
67. hypertonia
68. hypoesthesia
69. hypokalemia
70. hyponatremia
71. hypotension
72. impotence (erectile dysfunction)
73. increased urinary frequency
74. infection
75. infertility
76. influenza
77. insomnia
78. leukopenia
79. libido decrease
80. lymphadenopathy
81. malaise
82. mania
83. melena
84. memory impairment
85. miosis
86. muscle cramps
87. muscle paralysis
88. myalgia
89. myocardial infarction
90. nausea
91. nephrotic syndrome
92. nightmares
93. nocturia
94. ocular hemorrhage
95. ocular inflammation
96. ocular irritation
97. oliguria
98. oral ulceration
99. pallor
100. palpitations
101. pancreatitis
102. paresthesias
103. peptic ulcer
104. pericarditis
105. peripheral neuropathy
106. petechiae
107. pleural effusion
108. proteinuria
109. pruritus
110. psychosis
111. ptosis
112. purpura
113. pyuria
114. QT prolongation
115. rash
116. renal failure (unspecified)
117. rhinitis
118. seizures
119. SIADH
120. spermatogenesis inhibition
121. syncope
122. thrombocytopenia
123. thrombosis
124. tinnitus
125. torsade de pointes
126. tremor
127. urinary incontinence
128. urinary retention
129. urticaria
130. ventricular fibrillation
131. ventricular tachycardia
132. vertigo
133. visual impairment
134. vomiting
135. weakness
136. weight gain
137. weight loss
138. xerosis
139. xerostomia

Monitoring Parameters

• ECG

Contraindications

• acute bronchospasm
• alcoholism
• asthma
• AV block
• bradycardia
• breast-feeding
• Brugada syndrome
• cardiac arrhythmias
• cardiac disease
• cardiogenic shock
• chronic obstructive pulmonary disease (COPD)
• coronary artery disease
• diabetes mellitus
• electrolyte imbalance
• females
• geriatric
• heart failure
• hepatic disease
• hyperkalemia
• hypertension
• hypocalcemia
• hypokalemia
• hypomagnesemia
• hypotension
• infertility
• long QT syndrome
• malnutrition
• mortality
• myasthenia gravis
• myocardial infarction
• neonates
• pregnancy
• QT prolongation
• renal failure
• renal impairment
• sick sinus syndrome
• systemic lupus erythematosus (SLE)
• thyroid disease

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