Prilocaine and Epinephrine Brand Name– Citanest Forte
What is Prilocaine and Epinephrine
Prilocaine and epinephrine are used together in a parenteral preparation for local anesthesia.
Prilocaine is an amide anesthetic used for local anesthetic effects.
Epinephrine is a vasoconstrictor used to promote local hemostasis and to decrease systemic absorption and prolong duration of action of local anesthetics.
Prilocaine and Epinephrine was approved by the FDA in November 1965
Indications
- dental anesthesia
- inferior alveolar nerve block
- infiltration anesthesia
- local anesthesia
For local anesthesia in dentistry (dental anesthesia) including inferior alveolar nerve block and maxillary infiltration anesthesia.
Side Effects
- anaphylactoid reactions
- blurred vision
- bradycardia
- cardiac arrest
- confusion
- diaphoresis
- dizziness
- drowsiness
- edema
- euphoria
- hypotension
- hypoxia
- methemoglobinemia
- paresthesias
- rash
- respiratory arrest
- respiratory depression
- seizures
- tinnitus
- tremor
- urticaria
- vomiting
Monitoring Parameters
- glucose-6-phosphate dehydrogenase (G6PD) activity
Contraindications
- acute myocardial infarction
- amide local anesthetic hypersensitivity
- asthma
- AV block
- breast-feeding
- cardiac disease
- G6PD deficiency
- hepatic disease
- hypertension
- infants
- intraarterial administration
- intravenous administration
- malignant hyperthermia
- methemoglobinemia
- neonates
- peripheral vascular disease
- pregnancy
- pulmonary disease
- requires a specialized care setting
- shock
- sulfite hypersensitivity
Interactions
- Acarbose
- Acebutolol
- Acetaminophen
- Acetaminophen; Aspirin, ASA; Caffeine
- Acetaminophen; Butalbital
- Acetaminophen; Butalbital; Caffeine
- Acetaminophen; Butalbital; Caffeine; Codeine
- Acetaminophen; Caffeine
- Acetaminophen; Caffeine; Dihydrocodeine
- Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
- Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
- Acetaminophen; Codeine
- Acetaminophen; Dextromethorphan
- Acetaminophen; Dextromethorphan; Doxylamine
- Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
- Acetaminophen; Dextromethorphan; Phenylephrine
- Acetaminophen; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Dichloralphenazone; Isometheptene
- Acetaminophen; Diphenhydramine
- Acetaminophen; Guaifenesin; Phenylephrine
- Acetaminophen; Hydrocodone
- Acetaminophen; Oxycodone
- Acetaminophen; Pentazocine
- Acetaminophen; Propoxyphene
- Acetaminophen; Pseudoephedrine
- Acetaminophen; Tramadol
- Aclidinium; Formoterol
- Albiglutide
- Albuterol
- Albuterol; Ipratropium
- Alfentanil
- Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
- Aliskiren; Hydrochlorothiazide, HCTZ
- Alogliptin; Pioglitazone
- Alpha-blockers
- Alpha-glucosidase Inhibitors
- Ambenonium Chloride
- Ambrisentan
- Amiloride; Hydrochlorothiazide, HCTZ
- Aminosalicylate sodium, Aminosalicylic acid
- Amitriptyline
- Amitriptyline; Chlordiazepoxide
- Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
- Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
- Amobarbital
- Amoxapine
- Amyl Nitrite
- Arformoterol
- Articaine; Epinephrine
- Aspirin, ASA; Butalbital; Caffeine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Aspirin, ASA; Caffeine; Dihydrocodeine
- Aspirin, ASA; Caffeine; Orphenadrine
- Aspirin, ASA; Carisoprodol; Codeine
- Aspirin, ASA; Oxycodone
- Atazanavir
- Atazanavir; Cobicistat
- Atenolol
- Atenolol; Chlorthalidone
- Atomoxetine
- Atracurium
- Atropine; Edrophonium
- Atropine; Hyoscyamine; Phenobarbital; Scopolamine
- Azilsartan; Chlorthalidone
- Belladonna Alkaloids; Ergotamine; Phenobarbital
- Belladonna; Opium
- Benazepril; Hydrochlorothiazide, HCTZ
- Bendroflumethiazide; Nadolol
- Benzhydrocodone; Acetaminophen
- Benzonatate
- Beta-adrenergic blockers
- Beta-blockers
- Betaxolol
- Bethanechol
- Bisoprolol
- Bisoprolol; Hydrochlorothiazide, HCTZ
- Bosentan
- Bretylium
- Brimonidine; Timolol
- Bromocriptine
- Brompheniramine; Carbetapentane; Phenylephrine
- Brompheniramine; Dextromethorphan; Phenylephrine
- Brompheniramine; Guaifenesin; Hydrocodone
- Brompheniramine; Hydrocodone; Pseudoephedrine
- Budesonide; Formoterol
- Budesonide; Glycopyrrolate; Formoterol
- Bupivacaine
- Bupivacaine Liposomal
- Bupivacaine; Lidocaine
- Butyrophenone
- Caffeine
- Caffeine; Ergotamine
- Canagliflozin
- Canagliflozin; Metformin
- Candesartan; Hydrochlorothiazide, HCTZ
- Captopril; Hydrochlorothiazide, HCTZ
- Carbetapentane; Chlorpheniramine; Phenylephrine
- Carbetapentane; Diphenhydramine; Phenylephrine
- Carbetapentane; Guaifenesin; Phenylephrine
- Carbetapentane; Phenylephrine
- Carbetapentane; Phenylephrine; Pyrilamine
- Carbidopa; Levodopa; Entacapone
- Carbinoxamine; Hydrocodone; Phenylephrine
- Carbinoxamine; Hydrocodone; Pseudoephedrine
- Carbinoxamine; Phenylephrine
- Cardiac glycosides
- Carteolol
- Carvedilol
- Chlophedianol; Guaifenesin; Phenylephrine
- Chloroprocaine
- Chloroquine
- Chlorothiazide
- Chlorpheniramine; Codeine
- Chlorpheniramine; Dextromethorphan; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
- Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Hydrocodone
- Chlorpheniramine; Hydrocodone; Phenylephrine
- Chlorpheniramine; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Phenylephrine
- Chlorpromazine
- Chlorthalidone
- Chlorthalidone; Clonidine
- Cholinesterase inhibitors
- Cisatracurium
- Clomipramine
- Clonidine
- Clozapine
- Cocaine
- Codeine
- Codeine; Guaifenesin
- Codeine; Phenylephrine; Promethazine
- Codeine; Promethazine
- Colchicine
- Colchicine; Probenecid
- COMT inhibitors
- Cyclophosphamide
- Dapagliflozin
- Dapagliflozin; Metformin
- Dapagliflozin; Saxagliptin
- Dapsone
- Daratumumab; Hyaluronidase
- Desipramine
- Desmopressin
- Dextromethorphan; Diphenhydramine; Phenylephrine
- Dextromethorphan; Guaifenesin; Phenylephrine
- Dextromethorphan; Promethazine
- Dichlorphenamide
- Digitoxin
- Digoxin
- Dihydrocodeine; Guaifenesin; Pseudoephedrine
- Dihydroergotamine
- Dinoprostone, Prostaglandin E2
- Dipeptidyl Peptidase-4 Inhibitors
- Diphenhydramine; Hydrocodone; Phenylephrine
- Diphenhydramine; Phenylephrine
- Donepezil
- Donepezil; Memantine
- Dopamine
- Dorzolamide; Timolol
- Doxacurium
- Doxazosin
- Doxepin
- Dronabinol
- Droxidopa
- Dulaglutide
- Dyphylline
- Dyphylline; Guaifenesin
- Edrophonium
- Empagliflozin
- Empagliflozin; Linagliptin
- Empagliflozin; Linagliptin; Metformin
- Empagliflozin; Metformin
- Enalapril; Hydrochlorothiazide, HCTZ
- Enflurane
- Entacapone
- Ephedrine
- Epoprostenol
- Eprosartan; Hydrochlorothiazide, HCTZ
- Ergoloid Mesylates
- Ergonovine
- Ergot alkaloids
- Ergotamine
- Ertugliflozin
- Ertugliflozin; Metformin
- Ertugliflozin; Sitagliptin
- Esmolol
- Etomidate
- Exenatide
- Fentanyl
- Flecainide
- Fluoxetine; Olanzapine
- Fluphenazine
- Flutamide
- Fluticasone; Salmeterol
- Fluticasone; Umeclidinium; Vilanterol
- Fluticasone; Vilanterol
- food
- Formoterol
- Formoterol; Mometasone
- Fosinopril; Hydrochlorothiazide, HCTZ
- Fosphenytoin
- Fospropofol
- Galantamine
- General anesthetics
- Ginger, Zingiber officinale
- Glimepiride; Pioglitazone
- Glimepiride; Rosiglitazone
- Glycopyrrolate; Formoterol
- Green Tea
- Guaifenesin; Hydrocodone
- Guaifenesin; Hydrocodone; Pseudoephedrine
- Guaifenesin; Phenylephrine
- Guanabenz
- Halothane
- Homatropine; Hydrocodone
- Hyaluronidase
- Hyaluronidase, Recombinant; Immune Globulin
- Hydralazine; Hydrochlorothiazide, HCTZ
- Hydralazine; Isosorbide Dinitrate, ISDN
- Hydrochlorothiazide, HCTZ
- Hydrochlorothiazide, HCTZ; Irbesartan
- Hydrochlorothiazide, HCTZ; Lisinopril
- Hydrochlorothiazide, HCTZ; Losartan
- Hydrochlorothiazide, HCTZ; Methyldopa
- Hydrochlorothiazide, HCTZ; Metoprolol
- Hydrochlorothiazide, HCTZ; Moexipril
- Hydrochlorothiazide, HCTZ; Olmesartan
- Hydrochlorothiazide, HCTZ; Propranolol
- Hydrochlorothiazide, HCTZ; Quinapril
- Hydrochlorothiazide, HCTZ; Spironolactone
- Hydrochlorothiazide, HCTZ; Telmisartan
- Hydrochlorothiazide, HCTZ; Triamterene
- Hydrochlorothiazide, HCTZ; Valsartan
- Hydrocodone
- Hydrocodone; Ibuprofen
- Hydrocodone; Phenylephrine
- Hydrocodone; Potassium Guaiacolsulfonate
- Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
- Hydrocodone; Pseudoephedrine
- Hydromorphone
- Hydroxyurea
- Ibuprofen; Oxycodone
- Ifosfamide
- Iloprost
- Imipramine
- Incretin Mimetics
- Indacaterol
- Indacaterol; Glycopyrrolate
- Indapamide
- Insulin Degludec; Liraglutide
- Insulin Glargine; Lixisenatide
- Insulins
- Iobenguane I 131
- Isocarboxazid
- Isoflurane
- Isosorbide Dinitrate, ISDN
- Isosorbide Mononitrate
- Ketamine
- Labetalol
- Levalbuterol
- Levobetaxolol
- Levobunolol
- Levomethadyl
- Levomilnacipran
- Levorphanol
- Levothyroxine
- Levothyroxine; Liothyronine (Porcine)
- Levothyroxine; Liothyronine (Synthetic)
- Lidocaine
- Lidocaine; Prilocaine
- Linezolid
- Liothyronine
- Liraglutide
- Lixisenatide
- Loxapine
- Macitentan
- Magnesium Salts
- Maprotiline
- Mecamylamine
- Meglitinides
- Mepenzolate
- Meperidine
- Meperidine; Promethazine
- Mephobarbital
- Mepivacaine
- Mepivacaine; Levonordefrin
- Mesoridazine
- Metaproterenol
- Metformin; Pioglitazone
- Metformin; Rosiglitazone
- Methadone
- Methohexital
- Methyclothiazide
- Methyldopa
- Methylergonovine
- Methysergide
- Metoclopramide
- Metolazone
- Metoprolol
- Midodrine
- Miglitol
- Milnacipran
- Minocycline
- Mivacurium
- Monoamine oxidase inhibitors
- Morphine
- Morphine; Naltrexone
- Nabilone
- Nadolol
- Nebivolol
- Nebivolol; Valsartan
- Neostigmine
- Nesiritide, BNP
- Neuromuscular blockers
- Nicotine
- Nitrates
- Nitrofurantoin
- Nitroglycerin
- Norepinephrine
- Nortriptyline
- Olanzapine
- Oxycodone
- Oxymorphone
- Oxytocin
- Ozanimod
- Paliperidone
- Pancuronium
- Penbutolol
- Penicillin G Benzathine; Penicillin G Procaine
- Penicillin G Procaine
- Pergolide
- Perphenazine
- Perphenazine; Amitriptyline
- Phenelzine
- Phenobarbital
- Phenothiazines
- Phenoxybenzamine
- Phentolamine
- Phenylephrine
- Phenylephrine; Promethazine
- Phenytoin
- Physostigmine
- Pindolol
- Pioglitazone
- Pirbuterol
- Pramlintide
- Prazosin
- Primaquine
- Primidone
- Procarbazine
- Prochlorperazine
- Promethazine
- Propofol
- Propoxyphene
- Propranolol
- Protriptyline
- Pyridostigmine
- Quinine
- Rapacuronium
- Rasagiline
- Rasburicase
- Remifentanil
- Reserpine
- Riociguat
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- Rituximab; Hyaluronidase
- Rivastigmine
- Rocuronium
- Ropivacaine
- Rosiglitazone
- Safinamide
- Salmeterol
- Selegiline
- Selexipag
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- Sevoflurane
- SGLT2 Inhibitors
- Sibutramine
- Sotalol
- St. John’s Wort, Hypericum perforatum
- Succinylcholine
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- Sulfonamides
- Sulfonylureas
- Tacrine
- Terazosin
- Terbutaline
- Tetracaine
- Theophylline, Aminophylline
- Thiazide diuretics
- Thiazolidinediones
- Thiethylperazine
- Thiopental
- Thioridazine
- Thiothixene
- Thyroid hormones
- Timolol
- Tolcapone
- Tranylcypromine
- Trastuzumab; Hyaluronidase
- Treprostinil
- Tricyclic antidepressants
- Trifluoperazine
- Trimipramine
- Tubocurarine
- Umeclidinium; Vilanterol
- Valproic Acid, Divalproex Sodium
- Vasodilators
- Vasopressin, ADH
- Vasopressors
- Vecuronium
- Yohimbine
- Ziprasidone
