Pooled Plasma Solvent Detergent Treated

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Pooled Plasma Solvent Detergent Treated Brand Name– Octaplas

What is Pooled Plasma Solvent Detergent Treated

Pooled Plasma Solvent Detergent Treated is a parenteral, solvent/detergent treated ABO blood group-type specific pooled human plasma indicated for the replacement of multiple coagulation factors in patients with acquired deficiencies due to liver disease and those undergoing cardiac surgery or liver transplantation and for plasma exchange in patients with thrombotic thrombocytopenic purpura (TTP).

It is made from ABO blood group-type specific pooled human plasma, which is frozen to preserve the content of labile coagulation factors.

Solvent/detergent treated, pooled plasma can serve as an alternative to fresh frozen plasma (FFP). Solvent/detergent treated, pooled plasma contains plasma proteins such as albumin, immunoglobulins, other globulins, coagulation factors, complement proteins, and protease inhibitors.

The content and distribution of plasma proteins found in solvent/detergent treated, pooled plasma are similar to reference ranges for healthy donors, with the exceptions of protein S and alpha 2-antiplasmin, which are labile to solvent/detergent treatment and are controlled to ensure concentrations of 0.4 International Units/mL or more.

Indications

  • coagulation factor replacement
  • thrombotic thrombocytopenia purpura

For coagulation factor replacement in patients with acquired deficiencies due to liver disease or those undergoing cardiac surgery and liver transplant

Side Effects

  1. abdominal pain
  2. anaphylactic shock
  3. anaphylactoid reactions
  4. bleeding
  5. bronchospasm
  6. cardiac arrest
  7. chest pain (unspecified)
  8. chills
  9. dyspnea
  10. erythema
  11. fever
  12. headache
  13. heart failure
  14. hypervolemia
  15. hypocalcemia
  16. hypotension
  17. infusion-related reactions
  18. metabolic alkalosis
  19. nausea
  20. paresthesias
  21. pruritus
  22. pulmonary edema
  23. rash
  24. respiratory arrest
  25. sinus tachycardia
  26. tachypnea
  27. thromboembolism
  28. thrombosis
  29. urticaria
  30. vomiting

Monitoring Parameters

  • activated partial thromboplastin time (APTT)
  • prothrombin time (PT)

Contraindications

  • albumin hypersensitivity
  • breast-feeding
  • IgA deficiency
  • laboratory test interference
  • liver transplant
  • pregnancy
  • protein S deficiency
  • viral infection

Interactions

There are no drug interactions associated with Pooled Plasma, Solvent Detergent Treated products.

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