Pooled Plasma Solvent Detergent Treated Brand Name– Octaplas
What is Pooled Plasma Solvent Detergent Treated
Pooled Plasma Solvent Detergent Treated is a parenteral, solvent/detergent treated ABO blood group-type specific pooled human plasma indicated for the replacement of multiple coagulation factors in patients with acquired deficiencies due to liver disease and those undergoing cardiac surgery or liver transplantation and for plasma exchange in patients with thrombotic thrombocytopenic purpura (TTP).
It is made from ABO blood group-type specific pooled human plasma, which is frozen to preserve the content of labile coagulation factors.
Solvent/detergent treated, pooled plasma can serve as an alternative to fresh frozen plasma (FFP). Solvent/detergent treated, pooled plasma contains plasma proteins such as albumin, immunoglobulins, other globulins, coagulation factors, complement proteins, and protease inhibitors.
The content and distribution of plasma proteins found in solvent/detergent treated, pooled plasma are similar to reference ranges for healthy donors, with the exceptions of protein S and alpha 2-antiplasmin, which are labile to solvent/detergent treatment and are controlled to ensure concentrations of 0.4 International Units/mL or more.
- coagulation factor replacement
- thrombotic thrombocytopenia purpura
For coagulation factor replacement in patients with acquired deficiencies due to liver disease or those undergoing cardiac surgery and liver transplant
- abdominal pain
- anaphylactic shock
- anaphylactoid reactions
- cardiac arrest
- chest pain (unspecified)
- heart failure
- infusion-related reactions
- metabolic alkalosis
- pulmonary edema
- respiratory arrest
- sinus tachycardia
- activated partial thromboplastin time (APTT)
- prothrombin time (PT)
- albumin hypersensitivity
- IgA deficiency
- laboratory test interference
- liver transplant
- protein S deficiency
- viral infection
There are no drug interactions associated with Pooled Plasma, Solvent Detergent Treated products.