Polatuzumab Vedotin Brand Name– POLIVY
What is Polatuzumab Vedotin
Polatuzumab vedotin is a CD79b-directed antibody-drug conjugate. It is indicated in combination with bendamustine and a rituximab product for the treatment of adult patients with relapsed or refractory diffuse large B-cell lymphoma following at least 2 prior therapies.
The FDA has granted polatuzumab vedotin accelerated approval and breakthrough therapy status for this indication; further study is required to verify clinical benefit.
Severe myelosuppression has been reported with polatuzumab vedotin therapy.
Indications
- non-Hodgkin’s lymphoma (NHL)
For the treatment of non-Hodgkin’s lymphoma (NHL)
for the treatment of relapsed or refractory diffuse large B-cell lymphoma (DLBCL) following at least 2 prior therapies, in combination with bendamustine and rituximab
Side Effects
- anemia
- anemia
- anorexia
- anorexia
- antibody formation
- arthralgia
- blurred vision
- chills
- diarrhea
- diarrhea
- dizziness
- dyspnea
- elevated hepatic enzymes
- elevated hepatic enzymes
- fatigue
- fatigue
- fever
- fever
- flushing
- hyperamylasemia
- hypoalbuminemia
- hypoalbuminemia
- hypocalcemia
- hypocalcemia
- hypokalemia
- hypokalemia
- hypophosphatemia
- hypotension
- infection
- infection
- infusion-related reactions
- infusion-related reactions
- leukopenia
- leukopenia
- lymphopenia
- nephrotoxicity
- neutropenia
- neutropenia
- pancytopenia
- peripheral neuropathy
- peripheral neuropathy
- pneumonitis
- progressive multifocal leukoencephalopathy
- thrombocytopenia
- thrombocytopenia
- urticaria
- vomiting
- vomiting
- weight loss
- weight loss
Monitoring Parameters
- CBC with differential
- LFTs
- neurologic function
- pregnancy testing
- serum creatinine/BUN
- serum electrolytes
- serum uric acid
Contraindications
- anemia
- breast-feeding
- contraception requirements
- fungal infection
- hepatic disease
- herpes infection
- infection
- infertility
- infusion-related reactions
- male-mediated teratogenicity
- neutropenia
- peripheral neuropathy
- pregnancy
- pregnancy testing
- progressive multifocal leukoencephalopathy
- reproductive risk
- thrombocytopenia
- tumor lysis syndrome (TLS)
- viral infection
Interactions
- Amoxicillin; Clarithromycin; Lansoprazole
- Amoxicillin; Clarithromycin; Omeprazole
- Apalutamide
- Atazanavir
- Atazanavir; Cobicistat
- Atropine; Hyoscyamine; Phenobarbital; Scopolamine
- Belladonna Alkaloids; Ergotamine; Phenobarbital
- Carbamazepine
- Ceritinib
- Chloramphenicol
- Clarithromycin
- Cobicistat
- Conivaptan
- Darunavir
- Darunavir; Cobicistat
- Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
- Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
- Delavirdine
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
- Enzalutamide
- Fosamprenavir
- Fosphenytoin
- grapefruit juice
- Idelalisib
- Indinavir
- Isoniazid, INH; Pyrazinamide, PZA; Rifampin
- Isoniazid, INH; Rifampin
- Itraconazole
- Ketoconazole
- Lopinavir; Ritonavir
- Lumacaftor; Ivacaftor
- Lumacaftor; Ivacaftor
- Mifepristone
- Mitotane
- Nefazodone
- Nelfinavir
- Ombitasvir; Paritaprevir; Ritonavir
- Phenobarbital
- Phenytoin
- Posaconazole
- Primidone
- Ribociclib
- Ribociclib; Letrozole
- Rifampin
- Ritonavir
- Saquinavir
- St. John’s Wort, Hypericum perforatum
- Telithromycin
- Tipranavir
- Voriconazole
