Brentuximab vedotin

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Brentuximab vedotin Brand Name– ADCETRIS

What is Brentuximab vedotin

Brentuximab vedotin is an antibody-drug conjugate that targets CD30, a protein expressed on the surface of certain cancer cells.

It is indicated as a single-agent for consolidation therapy in adult patients with high-risk classical Hodgkin lymphoma (cHL) and for the treatment of adult patients with relapsed cHL, relapsed systemic anaplastic large-cell lymphoma (sALCL), or relapsed primary cutaneous anaplastic large-cell lymphoma or CD30-expressing mycosis fungoides.

Additionally, brentuximab vedotin is indicated in combination with doxorubicin, vinblastine, and dacarbazine in adults with previously untreated stage III or IV cHL and in combination with cyclophosphamide, doxorubicin, and prednisone in adults with previously untreated sALCL or other CD30-expressing peripheral T-cell lymphomas.

JC virus infection resulting in progressive multifocal leukoencephalopathy and death has been reported in patients who received brentuximab vedotin therapy.

Indications & Dosage

  • cutaneous T-cell lymphoma (CTCL)
  • Hodgkin lymphoma
  • mycosis fungoides
  • peripheral T-cell lymphoma (PTCL)
  • primary cutaneous anaplastic large-cell lymphoma
  • systemic anaplastic large-cell lymphoma

For the treatment of classical Hodgkin lymphoma

NOTE: Brentuximab has been designated an orphan drug by the FDA for this indication.

after failure of autologous hematopoietic stem cell transplant (auto-HSCT) or after failure of at least 2 prior multi-agent chemotherapy regimens in patients who are not auto-HSCT candidates

Side Effects

  1. abdominal pain
  2. abdominal pain
  3. acute respiratory distress syndrome (ARDS)
  4. alopecia
  5. anaphylactoid reactions
  6. anemia
  7. anemia
  8. anorexia
  9. anorexia
  10. antibody formation
  11. anxiety
  12. anxiety
  13. arthralgia
  14. arthralgia
  15. asthenia
  16. asthenia
  17. back pain
  18. back pain
  19. bone pain
  20. bone pain
  21. chills
  22. colitis
  23. confusion
  24. constipation
  25. constipation
  26. cough
  27. cough
  28. diabetic ketoacidosis
  29. diarrhea
  30. diarrhea
  31. dizziness
  32. dyspnea
  33. dyspnea
  34. edema
  35. edema
  36. elevated hepatic enzymes
  37. elevated hepatic enzymes
  38. enterocolitis
  39. fatigue
  40. fatigue
  41. fever
  42. fever
  43. GI bleeding
  44. GI obstruction
  45. GI perforation
  46. headache
  47. headache
  48. hyperbilirubinemia
  49. hyperesthesia
  50. hyperglycemia
  51. hyperglycemia
  52. hypoesthesia
  53. hypokalemia
  54. hypokalemia
  55. ileus
  56. infection
  57. infection
  58. infusion-related reactions
  59. infusion-related reactions
  60. insomnia
  61. insomnia
  62. interstitial lung disease
  63. lymphadenopathy
  64. lymphopenia
  65. lymphopenia
  66. maculopapular rash
  67. maculopapular rash
  68. memory impairment
  69. muscle cramps
  70. muscle cramps
  71. myalgia
  72. myalgia
  73. nausea
  74. nausea
  75. neuropathic pain
  76. neutropenia
  77. neutropenia
  78. night sweats
  79. oral ulceration
  80. oral ulceration
  81. pancreatitis
  82. paresthesias
  83. peptic ulcer
  84. peripheral edema
  85. peripheral neuropathy
  86. peripheral neuropathy
  87. pneumonitis
  88. pneumothorax
  89. progressive multifocal leukoencephalopathy
  90. pruritus
  91. pruritus
  92. pulmonary embolism
  93. rash
  94. rash
  95. Stevens-Johnson syndrome
  96. stomatitis
  97. stomatitis
  98. supraventricular tachycardia (SVT)
  99. thrombocytopenia
  100. thrombocytopenia
  101. toxic epidermal necrolysis
  102. tumor lysis syndrome (TLS)
  103. vesicular rash
  104. vesicular rash
  105. vomiting
  106. vomiting
  107. weakness
  108. weight loss
  109. weight loss
  110. xerosis

Monitoring Parameters

  • CBC with differential
  • LFTs
  • neurologic function
  • pregnancy testing
  • serum bilirubin (total and direct)
  • serum creatinine/BUN
  • serum electrolytes
  • serum uric acid

Contraindications

  • anemia
  • breast-feeding
  • colitis
  • contraception requirements
  • diabetes mellitus
  • geriatric
  • GI bleeding
  • GI disease
  • GI obstruction
  • GI perforation
  • hepatic disease
  • hyperglycemia
  • ileus
  • infection
  • infertility
  • infusion-related reactions
  • male-mediated teratogenicity
  • neutropenia
  • obesity
  • peptic ulcer disease
  • peripheral neuropathy
  • pneumonitis
  • pregnancy
  • pregnancy testing
  • progressive multifocal leukoencephalopathy
  • pulmonary disease
  • renal impairment
  • reproductive risk
  • respiratory distress syndrome
  • sepsis
  • thrombocytopenia
  • tumor lysis syndrome (TLS)

Interactions

  • Apalutamide
  • Aprepitant, Fosaprepitant
  • Atazanavir
  • Atazanavir; Cobicistat
  • Atropine; Hyoscyamine; Phenobarbital; Scopolamine
  • Belladonna Alkaloids; Ergotamine; Phenobarbital
  • Bleomycin
  • Boceprevir
  • Carbamazepine
  • Carbidopa
  • Carbidopa; Levodopa
  • Carbidopa; Levodopa; Entacapone
  • Ceritinib
  • Ciprofloxacin
  • Clozapine
  • Cobicistat
  • Darunavir
  • Darunavir; Cobicistat
  • Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
  • Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
  • Delavirdine
  • Dexamethasone
  • Efavirenz
  • Efavirenz; Emtricitabine; Tenofovir
  • Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
  • Elbasvir; Grazoprevir
  • Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
  • Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
  • Enzalutamide
  • Fosphenytoin
  • Idelalisib
  • Indinavir
  • Isavuconazonium
  • Isoniazid, INH; Pyrazinamide, PZA; Rifampin
  • Isoniazid, INH; Rifampin
  • Itraconazole
  • Ketoconazole
  • Lesinurad
  • Lesinurad; Allopurinol
  • Letermovir
  • Lopinavir; Ritonavir
  • Mephobarbital
  • Mitotane
  • Nevirapine
  • Ombitasvir; Paritaprevir; Ritonavir
  • Omeprazole; Amoxicillin; Rifabutin
  • Palifermin
  • Penicillamine
  • Phenobarbital
  • Phenytoin
  • Primidone
  • Ranolazine
  • Ribociclib
  • Ribociclib; Letrozole
  • Rifabutin
  • Rifampin
  • Rifapentine
  • Ritonavir
  • St. John’s Wort, Hypericum perforatum
  • Telithromycin
  • Telotristat Ethyl
  • Tipranavir
  • Tuberculin Purified Protein Derivative, PPD
  • Voriconazole

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