Pimavanserin Brand Name– NUPLAZID
What is Pimavanserin
Pimavanserin is an atypical antipsychotic indicated for the treatment of hallucinations and delusions associated with Parkinson’s disease psychosis.
In clinical trials, patients with a diagnosis of Parkinson’s Disease (PD) who had psychotic symptoms (hallucination and/or delusions) that started after PD diagnosis and were severe enough to warrant antipsychotic treatment were included for study.
As with other atypical antipsychotics, QT prolongation is possible. Similar to other atypical antipsychotics, pimavanserin administration is associated with an increased risk of all-cause death in elderly patients with dementia-related psychosis.
Pimavanserin is not approved for the treatment of patients with dementia-related psychosis unrelated to Parkinson’s disease psychosis.
Pimavanserin was approved by the FDA in April 2016.
Indications
- Parkinson’s disease psychosis
For the treatment of hallucinations and delusions associated with Parkinson’s disease psychosis
Side Effects
- agitation
- confusion
- constipation
- drowsiness
- edema
- fatigue
- hallucinations
- infection
- nausea
- peripheral edema
- QT prolongation
- rash
- stroke
- urticaria
Monitoring Parameters
- AIMS assessment
- neurologic function
- serum creatinine
- serum electrolytes
Contraindications
- apheresis
- AV block
- bradycardia
- breast-feeding
- cardiac arrhythmias
- cardiomyopathy
- celiac disease
- children
- dementia
- females
- fever
- geriatric
- heart failure
- human immunodeficiency virus (HIV) infection
- hyperparathyroidism
- hypocalcemia
- hypokalemia
- hypomagnesemia
- hypothermia
- hypothyroidism
- infants
- long QT syndrome
- myocardial infarction
- neonates
- pheochromocytoma
- pregnancy
- QT prolongation
- renal failure
- renal impairment
- rheumatoid arthritis
- sickle cell disease
- sleep deprivation
- stroke
- systemic lupus erythematosus (SLE)
Interactions
- Acetaminophen; Butalbital
- Acetaminophen; Butalbital; Caffeine
- Acetaminophen; Butalbital; Caffeine; Codeine
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- Albuterol
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- food
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