Pentoxifylline Brand Name– Pentopak | Pentoxil | Trental
What is Pentoxifylline
Pentoxifylline is a synthetic dimethylxanthine derivative that is structurally related to theophylline and caffeine.
Unlike these agents, pentoxifylline has hematological effects that are useful in the symptomatic treatment of complications of peripheral vascular diseases.
Pentoxifylline also has been used to manage acute and chronic cerebrovascular insufficiency, sickle cell disease, and painful diabetic neuropathy.
Pentoxifylline was approved by the FDA in August 1984.
Indications
- Behcet’s syndrome
- claudication
- diabetic neuropathy
- Kawasaki disease
- sickle cell disease
For the treatment of intermittent claudication associated with peripheral vascular disease
Side Effects
- anaphylactic shock
- anaphylactoid reactions
- angina
- angioedema
- anorexia
- anxiety
- aplastic anemia
- arrhythmia exacerbation
- aseptic meningitis
- blurred vision
- chest pain (unspecified)
- cholecystitis
- cholestasis
- confusion
- conjunctivitis
- constipation
- depression
- dyspnea
- edema
- elevated hepatic enzymes
- epistaxis
- flatulence
- hepatitis
- hypersalivation
- hypotension
- influenza
- jaundice
- laryngitis
- leukopenia
- malaise
- nasal congestion
- nausea
- pancytopenia
- pruritus
- purpura
- rash
- scotomata
- seizures
- sinus tachycardia
- thrombocytopenia
- urticaria
- vomiting
- weight gain
- weight loss
- xerostomia
Monitoring Parameters
- serum creatinine/BUN
Contraindications
- bleeding
- breast-feeding
- children
- geriatric
- intracranial bleeding
- peptic ulcer disease
- pregnancy
- renal failure
- renal impairment
- retinal bleeding
- surgery
Interactions
- Acarbose
- Acebutolol
- Acetaminophen; Aspirin, ASA; Caffeine
- Acetohexamide
- Albiglutide
- Aliskiren
- Aliskiren; Amlodipine
- Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
- Aliskiren; Hydrochlorothiazide, HCTZ
- Aliskiren; Valsartan
- Alogliptin; Metformin
- Alogliptin; Pioglitazone
- Alpha-glucosidase Inhibitors
- Ambrisentan
- Amiloride
- Amiloride; Hydrochlorothiazide, HCTZ
- Amlodipine
- Amlodipine; Atorvastatin
- Amlodipine; Benazepril
- Amlodipine; Celecoxib
- Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
- Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
- Amlodipine; Olmesartan
- Amlodipine; Telmisartan
- Amlodipine; Valsartan
- Angiotensin II receptor antagonists
- Angiotensin-converting enzyme inhibitors
- Aspirin, ASA
- Aspirin, ASA; Butalbital; Caffeine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Aspirin, ASA; Caffeine; Dihydrocodeine
- Aspirin, ASA; Caffeine; Orphenadrine
- Aspirin, ASA; Carisoprodol
- Aspirin, ASA; Carisoprodol; Codeine
- Aspirin, ASA; Citric Acid; Sodium Bicarbonate
- Aspirin, ASA; Dipyridamole
- Aspirin, ASA; Omeprazole
- Aspirin, ASA; Oxycodone
- Aspirin, ASA; Pravastatin
- Atenolol
- Atenolol; Chlorthalidone
- Azilsartan
- Azilsartan; Chlorthalidone
- Benazepril
- Benazepril; Hydrochlorothiazide, HCTZ
- Bendroflumethiazide; Nadolol
- Beta-adrenergic blockers
- Betaxolol
- Bisoprolol
- Bisoprolol; Hydrochlorothiazide, HCTZ
- Bosentan
- Brimonidine; Timolol
- Bumetanide
- Calcium-channel blockers
- Canagliflozin; Metformin
- Candesartan
- Candesartan; Hydrochlorothiazide, HCTZ
- Captopril
- Captopril; Hydrochlorothiazide, HCTZ
- Carteolol
- Carvedilol
- Central-acting adrenergic agents
- Chlorothiazide
- Chlorpropamide
- Chlorthalidone
- Chlorthalidone; Clonidine
- Cimetidine
- Ciprofloxacin
- Clevidipine
- Clofarabine
- Clonidine
- Dapagliflozin; Metformin
- Dapagliflozin; Saxagliptin
- Diazoxide
- Diltiazem
- Dorzolamide; Timolol
- Doxazosin
- Dulaglutide
- Empagliflozin; Linagliptin; Metformin
- Empagliflozin; Metformin
- Enalapril, Enalaprilat
- Enalapril; Felodipine
- Enalapril; Hydrochlorothiazide, HCTZ
- Eplerenone
- Epoprostenol
- Eprosartan
- Eprosartan; Hydrochlorothiazide, HCTZ
- Ertugliflozin; Metformin
- Ertugliflozin; Sitagliptin
- Esmolol
- Ethacrynic Acid
- Exenatide
- Felodipine
- Fenoldopam
- Fludarabine
- Fosinopril
- Fosinopril; Hydrochlorothiazide, HCTZ
- Furosemide
- Garlic, Allium sativum
- Ginger, Zingiber officinale
- Ginkgo, Ginkgo biloba
- Glimepiride
- Glimepiride; Pioglitazone
- Glimepiride; Rosiglitazone
- Glipizide
- Glipizide; Metformin
- Glyburide
- Glyburide; Metformin
- Guanabenz
- Guanfacine
- Hydralazine
- Hydralazine; Hydrochlorothiazide, HCTZ
- Hydralazine; Isosorbide Dinitrate, ISDN
- Hydrochlorothiazide, HCTZ
- Hydrochlorothiazide, HCTZ; Irbesartan
- Hydrochlorothiazide, HCTZ; Lisinopril
- Hydrochlorothiazide, HCTZ; Losartan
- Hydrochlorothiazide, HCTZ; Methyldopa
- Hydrochlorothiazide, HCTZ; Metoprolol
- Hydrochlorothiazide, HCTZ; Moexipril
- Hydrochlorothiazide, HCTZ; Olmesartan
- Hydrochlorothiazide, HCTZ; Propranolol
- Hydrochlorothiazide, HCTZ; Quinapril
- Hydrochlorothiazide, HCTZ; Spironolactone
- Hydrochlorothiazide, HCTZ; Telmisartan
- Hydrochlorothiazide, HCTZ; Triamterene
- Hydrochlorothiazide, HCTZ; Valsartan
- Iloprost
- Incretin Mimetics
- Indapamide
- Insulin Degludec; Liraglutide
- Insulin Glargine; Lixisenatide
- Insulins
- Irbesartan
- Isradipine
- Ketorolac
- Labetalol
- Levobetaxolol
- Levobunolol
- Linagliptin; Metformin
- Liraglutide
- Lisinopril
- Lixisenatide
- Loop diuretics
- Losartan
- Mecamylamine
- Meglitinides
- Metformin
- Metformin; Pioglitazone
- Metformin; Repaglinide
- Metformin; Rosiglitazone
- Metformin; Saxagliptin
- Metformin; Sitagliptin
- Methyclothiazide
- Methyldopa
- Metolazone
- Metoprolol
- Miglitol
- Minoxidil
- Moexipril
- Nadolol
- Nateglinide
- Nebivolol
- Nebivolol; Valsartan
- Nicardipine
- Nifedipine
- Nimodipine
- Nisoldipine
- Nitroprusside
- Olmesartan
- Penbutolol
- Perindopril
- Perindopril; Amlodipine
- Phenoxybenzamine
- Phentolamine
- Pindolol
- Pioglitazone
- Platelet Inhibitors
- Potassium-sparing diuretics
- Pramlintide
- Prazosin
- Propranolol
- Quinapril
- Ramipril
- Repaglinide
- Reserpine
- Rosiglitazone
- Sacubitril; Valsartan
- Saxagliptin
- Semaglutide
- Simvastatin; Sitagliptin
- Sitagliptin
- Spironolactone
- Sulfonylureas
- Telmisartan
- Terazosin
- Theophylline, Aminophylline
- Thiazide diuretics
- Thiazolidinediones
- Timolol
- Tolazamide
- Tolbutamide
- Torsemide
- Trandolapril
- Trandolapril; Verapamil
- Treprostinil
- Triamterene
- Valsartan
- Verapamil
- Warfarin
