Pentazocine Brand Name– Talwin
What is Pentazocine
Pentazocine is a synthetic opiate agonist-antagonist analgesic used to treat moderate to severe pain.
Commonly, pentazocine is considered to be one-sixth to one-third as potent as morphine.
At therapeutic doses, pentazocine has less respiratory depression than pure opiate agonists. Nausea, vomiting, and constipation are also less with pentazocine than morphine.
Pentazocine is not commonly used in clinical practice, due to the occurrence of dysphoric reactions and its relatively short duration of action.
Pentazocine was originally FDA-approved in 1967 as both an injection and single agent tablet, but only the intravenous form is currently available.
Indications
- general anesthesia induction
- general anesthesia maintenance
- moderate pain
- preanesthesia
- severe pain
For the treatment of moderate pain to severe pain
Side Effects
- abdominal pain
- adrenocortical insufficiency
- amenorrhea
- anaphylactic shock
- angioedema
- anorexia
- apnea
- blurred vision
- chills
- confusion
- constipation
- depression
- diarrhea
- diplopia
- dizziness
- drowsiness
- dysgeusia
- dysphoria
- dyspnea
- eosinophilia
- erythema multiforme
- euphoria
- flushing
- gonadal suppression
- hallucinations
- headache
- hyperhidrosis
- hypertension
- hyponatremia
- hypotension
- impotence (erectile dysfunction)
- increased intracranial pressure
- infertility
- injection site reaction
- insomnia
- irritability
- leukopenia
- libido decrease
- miosis
- nausea
- neonatal opioid withdrawal syndrome
- neutropenia
- nystagmus
- paresthesias
- physiological dependence
- pruritus
- psychological dependence
- rash
- respiratory depression
- scleral induration
- seizures
- serotonin syndrome
- SIADH
- sinus tachycardia
- skin ulcer
- Stevens-Johnson syndrome
- syncope
- tinnitus
- tolerance
- toxic epidermal necrolysis
- tremor
- urinary retention
- urticaria
- uterine contractions
- vomiting
- weakness
- withdrawal
- xerostomia
Monitoring Parameters
- laboratory monitoring not necessary
Contraindications
- abrupt discontinuation
- accidental exposure
- acute abdomen
- acute myocardial infarction
- adrenal insufficiency
- alcoholism
- angina
- asthma
- biliary tract disease
- bladder obstruction
- breast-feeding
- cardiac arrhythmias
- cardiac disease
- chronic obstructive pulmonary disease (COPD)
- CNS depression
- coadministration with other CNS depressants
- coma
- constipation
- cor pulmonale
- dehydration
- depression
- driving or operating machinery
- emphysema
- ethanol ingestion
- ethanol intoxication
- geriatric
- GI disease
- GI obstruction
- head trauma
- heart failure
- hepatic disease
- hypotension
- hypothyroidism
- hypovolemia
- hypoxemia
- ileus
- increased intracranial pressure
- infertility
- inflammatory bowel disease
- intracranial mass
- labor
- MAOI therapy
- myxedema
- neonatal opioid withdrawal syndrome
- obesity
- obstetric delivery
- oliguria
- orthostatic hypotension
- pancreatitis
- porphyria
- potential for overdose or poisoning
- pregnancy
- prostatic hypertrophy
- psychosis
- pulmonary disease
- renal failure
- renal impairment
- reproductive risk
- respiratory depression
- respiratory insufficiency
- scoliosis
- seizure disorder
- seizures
- shock
- sleep apnea
- status asthmaticus
- subcutaneous administration
- substance abuse
- sulfite hypersensitivity
- tobacco smoking
- ulcerative colitis
- urethral stricture
- urinary retention
- ventricular dysfunction
Interactions
- Acetaminophen; Butalbital
- Acetaminophen; Butalbital; Caffeine
- Acetaminophen; Butalbital; Caffeine; Codeine
- Acetaminophen; Caffeine; Dihydrocodeine
- Acetaminophen; Codeine
- Acetaminophen; Hydrocodone
- Acetaminophen; Oxycodone
- Acetaminophen; Propoxyphene
- Acetaminophen; Tramadol
- Alfentanil
- Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
- Aliskiren; Hydrochlorothiazide, HCTZ
- Alprazolam
- Amantadine
- Amifampridine
- Amiloride
- Amiloride; Hydrochlorothiazide, HCTZ
- Amitriptyline; Chlordiazepoxide
- Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
- Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
- Amobarbital
- Amoxapine
- Anticholinergics
- Aripiprazole
- Asenapine
- Aspirin, ASA; Butalbital; Caffeine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Aspirin, ASA; Caffeine; Dihydrocodeine
- Aspirin, ASA; Carisoprodol; Codeine
- Aspirin, ASA; Oxycodone
- Atenolol; Chlorthalidone
- Atropine
- Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
- Atropine; Difenoxin
- Atropine; Diphenoxylate
- Atropine; Edrophonium
- Atropine; Hyoscyamine; Phenobarbital; Scopolamine
- atypical antipsychotic
- Azelastine
- Azelastine; Fluticasone
- Azilsartan; Chlorthalidone
- Barbiturates
- Belladonna Alkaloids; Ergotamine; Phenobarbital
- Belladonna; Opium
- Benazepril; Hydrochlorothiazide, HCTZ
- Bendroflumethiazide; Nadolol
- Benzhydrocodone; Acetaminophen
- Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
- Benztropine
- Bisoprolol; Hydrochlorothiazide, HCTZ
- Brexpiprazole
- Brompheniramine; Carbetapentane; Phenylephrine
- Brompheniramine; Guaifenesin; Hydrocodone
- Brompheniramine; Hydrocodone; Pseudoephedrine
- Bumetanide
- Buprenorphine
- Buprenorphine; Naloxone
- Bupropion
- Bupropion; Naltrexone
- Buspirone
- Butabarbital
- Butorphanol
- Candesartan; Hydrochlorothiazide, HCTZ
- Cannabidiol
- Captopril; Hydrochlorothiazide, HCTZ
- Carbetapentane; Chlorpheniramine
- Carbetapentane; Chlorpheniramine; Phenylephrine
- Carbetapentane; Diphenhydramine; Phenylephrine
- Carbetapentane; Guaifenesin
- Carbetapentane; Guaifenesin; Phenylephrine
- Carbetapentane; Phenylephrine
- Carbetapentane; Phenylephrine; Pyrilamine
- Carbetapentane; Pseudoephedrine
- Carbetapentane; Pyrilamine
- Carbidopa; Levodopa; Entacapone
- Carbinoxamine; Hydrocodone; Phenylephrine
- Carbinoxamine; Hydrocodone; Pseudoephedrine
- Cariprazine
- Cenobamate
- Cetirizine
- Cetirizine; Pseudoephedrine
- Chlordiazepoxide
- Chlordiazepoxide; Clidinium
- Chlorothiazide
- Chlorpheniramine; Codeine
- Chlorpheniramine; Dihydrocodeine; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
- Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Hydrocodone
- Chlorpheniramine; Hydrocodone; Phenylephrine
- Chlorpheniramine; Hydrocodone; Pseudoephedrine
- Chlorpromazine
- Chlorthalidone
- Chlorthalidone; Clonidine
- Clobazam
- Clonazepam
- Clorazepate
- Clozapine
- Codeine
- Codeine; Guaifenesin
- Codeine; Phenylephrine; Promethazine
- Codeine; Promethazine
- COMT inhibitors
- Deutetrabenazine
- Dextromethorphan; Promethazine
- Diazepam
- Dicyclomine
- Dihydrocodeine; Guaifenesin; Pseudoephedrine
- Diphenhydramine; Hydrocodone; Phenylephrine
- Disopyramide
- Dronabinol
- Droperidol
- Enalapril; Hydrochlorothiazide, HCTZ
- Entacapone
- Eprosartan; Hydrochlorothiazide, HCTZ
- Esketamine
- Estazolam
- Eszopiclone
- Ethacrynic Acid
- Ethanol
- Ezogabine
- Fenfluramine
- Fentanyl
- Flavoxate
- Flibanserin
- Fluoxetine; Olanzapine
- Fluphenazine
- Flurazepam
- Fosinopril; Hydrochlorothiazide, HCTZ
- Furosemide
- Gabapentin
- Glycopyrrolate
- Glycopyrrolate; Formoterol
- Guaifenesin; Hydrocodone
- Guaifenesin; Hydrocodone; Pseudoephedrine
- Haloperidol
- Homatropine; Hydrocodone
- Hydralazine; Hydrochlorothiazide, HCTZ
- Hydrochlorothiazide, HCTZ
- Hydrochlorothiazide, HCTZ; Irbesartan
- Hydrochlorothiazide, HCTZ; Lisinopril
- Hydrochlorothiazide, HCTZ; Losartan
- Hydrochlorothiazide, HCTZ; Methyldopa
- Hydrochlorothiazide, HCTZ; Metoprolol
- Hydrochlorothiazide, HCTZ; Moexipril
- Hydrochlorothiazide, HCTZ; Olmesartan
- Hydrochlorothiazide, HCTZ; Propranolol
- Hydrochlorothiazide, HCTZ; Quinapril
- Hydrochlorothiazide, HCTZ; Spironolactone
- Hydrochlorothiazide, HCTZ; Telmisartan
- Hydrochlorothiazide, HCTZ; Triamterene
- Hydrochlorothiazide, HCTZ; Valsartan
- Hydrocodone
- Hydrocodone; Ibuprofen
- Hydrocodone; Phenylephrine
- Hydrocodone; Potassium Guaiacolsulfonate
- Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
- Hydrocodone; Pseudoephedrine
- Hydromorphone
- Hyoscyamine
- Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
- Ibuprofen; Oxycodone
- Iloperidone
- Indacaterol; Glycopyrrolate
- Indapamide
- Lasmiditan
- Lemborexant
- Levocetirizine
- Levomethadyl
- Levorphanol
- Linezolid
- Lofexidine
- Loop diuretics
- Lorazepam
- Lumateperone
- Lurasidone
- Magnesium Salts
- Maprotiline
- Mepenzolate
- Meperidine
- Meperidine; Promethazine
- Mephobarbital
- Meprobamate
- Mesoridazine
- Methadone
- Methenamine; Sodium Acid Phosphate; Methylene Blue; Hyoscyamine
- Methocarbamol
- Methohexital
- Methscopolamine
- Methyclothiazide
- Methylene Blue
- Metolazone
- Midazolam
- Minocycline
- Mirtazapine
- Molindone
- Monoamine oxidase inhibitors
- Morphine
- Morphine; Naltrexone
- Nabilone
- Nalbuphine
- Nalmefene
- Naloxone
- Naltrexone
- Nefazodone
- Olanzapine
- Oxazepam
- Oxybutynin
- Oxycodone
- Oxymorphone
- Ozanimod
- Paliperidone
- Pentazocine; Naloxone
- Pentobarbital
- Perphenazine
- Perphenazine; Amitriptyline
- Phenobarbital
- Phenothiazines
- Phenylephrine; Promethazine
- Pimozide
- Potassium-sparing diuretics
- Pramipexole
- Pregabalin
- Primidone
- Procarbazine
- Prochlorperazine
- Promethazine
- Propantheline
- Propoxyphene
- Quazepam
- Quetiapine
- Rasagiline
- Remifentanil
- Risperidone
- Rotigotine
- Safinamide
- Scopolamine
- Secobarbital
- Sedating H1-blockers
- Selective serotonin reuptake inhibitors
- Selegiline
- Serotonin norepinephrine reuptake inhibitors
- Sibutramine
- Skeletal Muscle Relaxants
- Solifenacin
- Spironolactone
- Sufentanil
- Suvorexant
- Tapentadol
- Tedizolid
- Temazepam
- Tetrabenazine
- Thalidomide
- Thiazide diuretics
- Thiethylperazine
- Thiopental
- Thioridazine
- Thiothixene
- Tizanidine
- tobacco
- Tolcapone
- Tolterodine
- Torsemide
- Tramadol
- Trazodone
- Triamterene
- Triazolam
- Tricyclic antidepressants
- Trifluoperazine
- Trihexyphenidyl
- Trimethobenzamide
- Trospium
- Vigabatrin
- Vilazodone
- Vortioxetine
- Zaleplon
- Ziconotide
- Ziprasidone
- Zolpidem
