Pemigatinib Brand Name– Pemazyre
What is Pemigatinib
Pemigatinib is an oral small molecule kinase inhibitor that targets fibroblast growth factor receptors (FGFR) 1, 2, and 3.
It is indicated for the treatment of adults with previously treated, unresectable locally advanced or metastatic cholangiocarcinoma with an FGFR2 fusion or other rearrangement as detected by an FDA-approved test.
Comprehensive ophthalmological examinations are necessary prior to beginning therapy and throughout treatment due to the risk of retinal pigment epithelial detachment.
Increases in serum phosphate levels are also a pharmacodynamic effect of pemigatinib; monitor for hyperphosphatemia.
Indications
- cholangiocarcinoma
For the treatment of cholangiocarcinoma
NOTE: Pemigatinib is designated by the FDA as an orphan drug for this indication.
for the treatment of previously treated, unresectable locally advanced or metastatic cholangiocarcinoma with a fibroblast growth factor receptor 2 (FGFR2) fusion or other rearrangement
Side Effects
- abdominal pain
- abdominal pain
- alopecia
- anemia
- anemia
- anorexia
- anorexia
- arthralgia
- arthralgia
- back pain
- back pain
- blurred vision
- bone fractures
- cholangitis
- constipation
- constipation
- dehydration
- dehydration
- diarrhea
- diarrhea
- dysgeusia
- elevated hepatic enzymes
- elevated hepatic enzymes
- fatigue
- fatigue
- fever
- GI obstruction
- headache
- hyperbilirubinemia
- hyperbilirubinemia
- hypercalcemia
- hypercalcemia
- hyperglycemia
- hyperglycemia
- hyperkalemia
- hyperkalemia
- hyperphosphatemia
- hypoalbuminemia
- hypocalcemia
- hypocalcemia
- hypoglycemia
- hypoglycemia
- hypokalemia
- hypokalemia
- hyponatremia
- hyponatremia
- hypophosphatemia
- hypophosphatemia
- hypotension
- infection
- infection
- keratitis
- lacrimation
- leukocytosis
- leukocytosis
- leukopenia
- leukopenia
- lymphopenia
- lymphopenia
- nail discoloration
- nausea
- nausea
- onycholysis
- Onychomadesis
- palmar-plantar erythrodysesthesia (hand and foot syndrome)
- palmar-plantar erythrodysesthesia (hand and foot syndrome)
- peripheral edema
- peripheral edema
- photopsia
- pleural effusion
- QT prolongation
- renal failure (unspecified)
- retinal detachment
- retinal detachment
- stomatitis
- stomatitis
- syncope
- thrombocytopenia
- thrombocytopenia
- vomiting
- vomiting
- weight loss
- weight loss
- xerophthalmia
- xerophthalmia
- xerosis
- xerosis
- xerostomia
Monitoring Parameters
- ophthalmologic exam
- pregnancy testing
- serum phosphate
Contraindications
- breast-feeding
- contraception requirements
- hyperphosphatemia
- male-mediated teratogenicity
- pregnancy
- pregnancy testing
- renal impairment
- reproductive risk
- retinal detachment
Interactions
- Acetaminophen; Butalbital
- Acetaminophen; Butalbital; Caffeine
- Acetaminophen; Butalbital; Caffeine; Codeine
- Amiodarone
- Amobarbital
- Amoxicillin; Clarithromycin; Lansoprazole
- Amoxicillin; Clarithromycin; Omeprazole
- Apalutamide
- Aprepitant, Fosaprepitant
- Aspirin, ASA; Butalbital; Caffeine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Atazanavir
- Atazanavir; Cobicistat
- Bexarotene
- Bosentan
- Brigatinib
- Butabarbital
- Carbamazepine
- Cenobamate
- Ceritinib
- Chloramphenicol
- Ciprofloxacin
- Clarithromycin
- Cobicistat
- Conivaptan
- Crizotinib
- Cyclosporine
- Dabrafenib
- Danazol
- Darunavir
- Darunavir; Cobicistat
- Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
- Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
- Delavirdine
- Dexamethasone
- Diltiazem
- Dronedarone
- Duvelisib
- Efavirenz
- Efavirenz; Emtricitabine; Tenofovir
- Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
- Elagolix
- Elagolix; Estradiol; Norethindrone acetate
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
- Enzalutamide
- Erythromycin
- Erythromycin; Sulfisoxazole
- Eslicarbazepine
- Etravirine
- Fedratinib
- Fluconazole
- Fluvoxamine
- Fosamprenavir
- Fosphenytoin
- grapefruit juice
- Idelalisib
- Imatinib
- Indinavir
- Isavuconazonium
- Isoniazid, INH; Pyrazinamide, PZA; Rifampin
- Isoniazid, INH; Rifampin
- Itraconazole
- Ketoconazole
- Letermovir
- Lopinavir; Ritonavir
- Lorlatinib
- Lumacaftor; Ivacaftor
- Lumacaftor; Ivacaftor
- Mephobarbital
- Methohexital
- Mifepristone
- Mitotane
- Modafinil
- Nafcillin
- Nefazodone
- Nelfinavir
- Netupitant, Fosnetupitant; Palonosetron
- Nevirapine
- Nilotinib
- Ombitasvir; Paritaprevir; Ritonavir
- Omeprazole; Amoxicillin; Rifabutin
- Pentobarbital
- Phenytoin
- Posaconazole
- Primidone
- Ribociclib
- Ribociclib; Letrozole
- Rifabutin
- Rifampin
- Rifapentine
- Ritonavir
- Saquinavir
- Secobarbital
- St. John’s Wort, Hypericum perforatum
- Telithromycin
- Thiopental
- Tipranavir
- Trandolapril; Verapamil
- Tucatinib
- Verapamil
- Voriconazole
