Pegvisomant

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Pegvisomant Brand Names- Somavert | Somavert Kit

What is Pegvisomant

Pegvisomant is a growth hormone receptor antagonist, designed to block the effects of excessive growth hormone production by pituitary gland tumors. The drug is given subcutaneously and is used specifically for the treatment of acromegaly.

Pegvisomant is an analog of human growth hormone that has been structurally altered to act as a growth hormone receptor antagonist.

Pegvisomant is a protein of recombinant DNA origin, synthesized using Escherichia coli bacteria, containing 191 amino acid residues to which several polyethylene glycol polymers are covalently bound.

Rather than inhibiting growth hormone secretion from the tumor, as do current medical treatments for acromegaly (e.g., dopamine-agonists and somatostatin analogues) pegvisomant blocks the action of growth hormone at the tissue level.

Pegvisomant has an established efficacy and tolerability profile for the treatment of acromegaly

Indications

  • acromegaly

For the treatment of acromegaly in patients who have had an inadequate response to surgery and/or radiation therapy and/or other medical therapies, or for whom these therapies are not appropriate

Side Effects

  1. anaphylactoid reactions
  2. angioedema
  3. antibody formation
  4. back pain
  5. chest pain (unspecified)
  6. diarrhea
  7. dizziness
  8. elevated hepatic enzymes
  9. erythema
  10. hepatitis
  11. hypertension
  12. infection
  13. injection site reaction
  14. jaundice
  15. laryngospasm
  16. lipodystrophy
  17. nausea
  18. paresthesias
  19. peripheral edema
  20. pruritus
  21. rash
  22. sinusitis
  23. urticaria
  24. weight gain

Monitoring Parameters

  • blood glucose
  • blood pressure
  • LFTs
  • serum IGF-1 concentrations
  • serum lipid profile

Contraindications

  • breast-feeding
  • children
  • diabetes mellitus
  • hepatic disease
  • infants
  • laboratory test interference
  • neonates
  • neoplastic disease
  • pregnancy

Interactions

  • Acarbose
  • Acetaminophen; Butalbital; Caffeine; Codeine
  • Acetaminophen; Caffeine; Dihydrocodeine
  • Acetaminophen; Codeine
  • Acetaminophen; Hydrocodone
  • Acetaminophen; Oxycodone
  • Acetaminophen; Propoxyphene
  • Acetohexamide
  • Albiglutide
  • Alfentanil
  • Alogliptin
  • Alogliptin; Metformin
  • Alogliptin; Pioglitazone
  • Antidiabetic Agents
  • Aspirin, ASA; Butalbital; Caffeine; Codeine
  • Aspirin, ASA; Caffeine; Dihydrocodeine
  • Aspirin, ASA; Carisoprodol; Codeine
  • Aspirin, ASA; Oxycodone
  • Atropine; Difenoxin
  • Atropine; Diphenoxylate
  • Belladonna; Opium
  • Bromocriptine
  • Brompheniramine; Guaifenesin; Hydrocodone
  • Brompheniramine; Hydrocodone; Pseudoephedrine
  • Canagliflozin
  • Canagliflozin; Metformin
  • Carbinoxamine; Hydrocodone; Phenylephrine
  • Carbinoxamine; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Codeine
  • Chlorpheniramine; Dihydrocodeine; Phenylephrine
  • Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
  • Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Hydrocodone
  • Chlorpheniramine; Hydrocodone; Phenylephrine
  • Chlorpheniramine; Hydrocodone; Pseudoephedrine
  • Chlorpropamide
  • Codeine
  • Codeine; Guaifenesin
  • Codeine; Phenylephrine; Promethazine
  • Codeine; Promethazine
  • Dapagliflozin
  • Dapagliflozin; Metformin
  • Dapagliflozin; Saxagliptin
  • Dihydrocodeine; Guaifenesin; Pseudoephedrine
  • Diphenhydramine; Hydrocodone; Phenylephrine
  • Dulaglutide
  • Empagliflozin
  • Empagliflozin; Linagliptin
  • Empagliflozin; Linagliptin; Metformin
  • Empagliflozin; Metformin
  • Ertugliflozin
  • Ertugliflozin; Metformin
  • Ertugliflozin; Sitagliptin
  • Exenatide
  • Fentanyl
  • Glimepiride
  • Glimepiride; Pioglitazone
  • Glimepiride; Rosiglitazone
  • Glipizide
  • Glipizide; Metformin
  • Glyburide
  • Glyburide; Metformin
  • Guaifenesin; Hydrocodone
  • Guaifenesin; Hydrocodone; Pseudoephedrine
  • Homatropine; Hydrocodone
  • Hydrocodone
  • Hydrocodone; Ibuprofen
  • Hydrocodone; Phenylephrine
  • Hydrocodone; Potassium Guaiacolsulfonate
  • Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
  • Hydrocodone; Pseudoephedrine
  • Hydromorphone
  • Ibuprofen; Oxycodone
  • Insulin Aspart
  • Insulin Aspart; Insulin Aspart Protamine
  • Insulin Degludec; Liraglutide
  • Insulin Detemir
  • Insulin Glargine
  • Insulin Glargine; Lixisenatide
  • Insulin Glulisine
  • Insulin Lispro
  • Insulin Lispro; Insulin Lispro Protamine
  • Insulin, Inhaled
  • Isophane Insulin (NPH)
  • Lente Insulin
  • Levorphanol
  • Linagliptin
  • Linagliptin; Metformin
  • Liraglutide
  • Lixisenatide
  • Mecasermin rinfabate
  • Mecasermin, Recombinant, rh-IGF-1
  • Meperidine
  • Meperidine; Promethazine
  • Metformin
  • Metformin; Pioglitazone
  • Metformin; Repaglinide
  • Metformin; Rosiglitazone
  • Metformin; Saxagliptin
  • Metformin; Sitagliptin
  • Methadone
  • Miglitol
  • Morphine
  • Morphine; Naltrexone
  • Nateglinide
  • Opiate Agonists
  • Oxycodone
  • Oxymorphone
  • Pioglitazone
  • Pramlintide
  • Propoxyphene
  • Regular Insulin
  • Regular Insulin; Isophane Insulin (NPH)
  • Remifentanil
  • Repaglinide
  • Rosiglitazone
  • Saxagliptin
  • Semaglutide
  • Simvastatin; Sitagliptin
  • Sitagliptin
  • Sufentanil
  • Tolazamide
  • Tolbutamide
  • Ultralente Insulin

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