Pegfilgrastim Brand Name– Fulphila | Neulasta | Ziextenzo
What is Pegfilgrastim
Pegfilgrastim is a leukocyte growth factor that binds to cell surface receptors on hematopoietic cells stimulating proliferation, differentiation, commitment, and end cell functional activation.
It is indicated to increase survival in patients acutely exposed to myelosuppressive doses of radiation. Efficacy for this indication was based on animal data in monkeys.
Pegfilgrastim and biosimilar products (i.e., pegfilgrastim-bmez, pegfilgrastim-jmdb, and pegfilgrastim-cbqv) are indicated to decrease the incidence of infection, as manifested by febrile neutropenia, in patients with non-myeloid malignancies receiving myelosuppressive anticancer drugs associated with a clinically significant incidence of febrile neutropenia.
None of these products are indicated for the mobilization of peripheral blood progenitor cells for hematopoietic stem-cell transplantation.
Acute respiratory distress syndrome, fatal splenic rupture, and glomerulonephritis have occurred with pegfilgrastim products
Indications
- chemotherapy-induced neutropenia
- radiation exposure
For chemotherapy-induced neutropenia prophylaxis, to decrease the incidence of febrile neutropenia, in patients with nonmyeloid malignancies receiving myelosuppressive chemotherapy associated with a clinically significant incidence of febrile neutropenia
Side Effects
- abdominal pain
- acute respiratory distress syndrome (ARDS)
- anaphylactoid reactions
- antibody formation
- aortitis
- azotemia
- back pain
- bleeding
- bone pain
- capillary leak syndrome
- contact dermatitis
- edema
- erythema
- fever
- flushing
- glomerulonephritis
- hematuria
- hypoalbuminemia
- hypotension
- injection site reaction
- leukocytosis
- malaise
- proteinuria
- pruritus
- rash
- sickle-cell crisis
- splenic rupture
- splenomegaly
- urticaria
- vasculitis
Monitoring Parameters
- CBC with differential
- platelet count
Contraindications
- breast-feeding
- E. coli protein hypersensitivity
- leukemia
- leukocytosis
- pregnancy
- sickle cell disease
Interactions
- Abemaciclib
- Aldesleukin, IL-2
- Alemtuzumab
- Alpha interferons
- Altretamine
- Antimetabolites
- Antitumor antibiotics
- Bexarotene
- Busulfan
- Clofarabine
- Cyclophosphamide
- Dacarbazine, DTIC
- Denileukin Diftitox
- Ibritumomab Tiuxetan
- Lithium
- Methotrexate
- Mitoxantrone
- Natural Antineoplastics
- Nelarabine
- Nitrosoureas
- Procarbazine
- Purine analogs
- Temozolomide
- Thiotepa
- Tositumomab
- Tretinoin, ATRA
