Pazopanib

Pazopanib Brand Name– Votrient

What is Pazopanib

Pazopanib (Votrient) is an oral multikinase angiogenesis inhibitor.

It targets the vascular endothelial growth factor receptor (VEGFR)-1, VEGFR-2, and VEGFR-3; platelet-derived growth factor (PDGF) receptor; fibroblast growth factor receptor (FGFR)-1 and FGFR-3; cytokine receptor (Kit); interleukin-2 receptor inducible T-cell kinase; leukocyte-specific protein tyrosine kinase; and transmembrane glycoprotein receptor tyrosine kinase.

Pazopanib has been investigated for the treatment of renal cell carcinoma, soft tissue sarcomas, breast cancer, ovarian cancer, as well as other solid tumors and hematologic malignancies.

In October 2009, pazopanib received FDA approval for the treatment of advanced renal cell carcinoma.

In April 2012, pazopanib received FDA approval for the treatment of advanced soft-tissue sarcoma in patients who have received prior chemotherapy.

Indications

• gastrointestinal stromal tumors (GIST)
• renal cell cancer
• soft-tissue sarcoma

For the treatment of advanced renal cell cancer

Side Effects

1. abdominal pain
2. abdominal pain
3. alopecia
4. anorexia
5. anorexia
6. aortic dissection
7. arthralgia
8. asthenia
9. asthenia
10. bleeding
11. bleeding
12. blurred vision
13. bradycardia
14. chest pain (unspecified)
15. chest pain (unspecified)
16. chills
17. cough
18. cough
19. diarrhea
20. diarrhea
21. dizziness
22. dizziness
23. dysgeusia
24. dyspepsia
25. dysphonia
26. dyspnea
27. dyspnea
28. edema
29. elevated hepatic enzymes
30. elevated hepatic enzymes
31. epistaxis
32. fatigue
33. fatigue
34. gastrointestinal fistula
35. GI bleeding
36. GI perforation
37. hair discoloration
38. hair discoloration
39. headache
40. headache
41. heart failure
42. hematuria
43. hemolytic-uremic syndrome
44. hemoptysis
45. hepatic failure
46. hepatotoxicity
47. hyperbilirubinemia
48. hyperbilirubinemia
49. hyperglycemia
50. hyperglycemia
51. hyperkalemia
52. hypertension
53. hypertension
54. hypertensive crisis
55. hypoalbuminemia
56. hypoalbuminemia
57. hypoglycemia
58. hypoglycemia
59. hypomagnesemia
60. hypomagnesemia
61. hyponatremia
62. hyponatremia
63. hypophosphatemia
64. hypophosphatemia
65. hypothyroidism
66. infection
67. insomnia
68. intracranial bleeding
69. leukoencephalopathy
70. leukopenia
71. leukopenia
72. lymphopenia
73. lymphopenia
74. muscle cramps
75. musculoskeletal pain
76. musculoskeletal pain
77. myalgia
78. myalgia
79. myocardial infarction
80. nausea
81. nausea
82. nephrotic syndrome
83. neutropenia
84. neutropenia
85. palmar-plantar erythrodysesthesia (hand and foot syndrome)
86. palmar-plantar erythrodysesthesia (hand and foot syndrome)
87. pancreatitis
88. peripheral edema
89. peripheral edema
90. pneumonitis
91. pneumothorax
92. polycythemia
93. proteinuria
94. pulmonary embolism
95. QT prolongation
96. rash
97. rash
98. retinal detachment
99. skin hypopigmentation
100. stomatitis
101. stomatitis
102. stroke
103. thrombocytopenia
104. thrombocytopenia
105. thrombosis
106. thrombotic microangiopathy
107. thrombotic thrombocytopenic purpura (TTP)
108. torsade de pointes
109. tumor lysis syndrome (TLS)
110. vomiting
111. vomiting
112. weight loss
113. weight loss
114. xerosis

Monitoring Parameters

• CBC with differential
• ECG
• LFTs
• pregnancy testing
• serum bilirubin
• serum electrolytes
• thyroid function tests (TFTs)
• urinalysis

Contraindications

• angina
• apheresis
• Asian patients
• AV block
• bleeding
• bradycardia
• breast-feeding
• cardiomyopathy
• celiac disease
• children
• contraception requirements
• dehydration
• females
• fever
• geriatric
• GI bleeding
• heart failure
• hemolytic-uremic syndrome
• hepatic disease
• hepatotoxicity
• human immunodeficiency virus (HIV) infection
• hyperparathyroidism
• hypertension
• hypocalcemia
• hypokalemia
• hypomagnesemia
• hypothermia
• hypothyroidism
• infants
• infertility
• intracranial bleeding
• long QT syndrome
• male-mediated teratogenicity
• myocardial infarction
• neonates
• neutropenia
• pheochromocytoma
• pneumonitis
• pregnancy
• pregnancy testing
• proteinuria
• QT prolongation
• renal impairment
• reproductive risk
• rheumatoid arthritis
• serious rash
• sickle cell disease
• sleep deprivation
• stroke
• surgery
• systemic lupus erythematosus (SLE)
• thrombocytopenia
• thrombotic thrombocytopenic purpura (TTP)
• tumor lysis syndrome (TLS)
• wound dehiscence

Interactions

• Acalabrutinib
• Acetaminophen; Caffeine; Dihydrocodeine
• Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
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