Pancrelipase

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Pancrelipase Brand Names

Cotazym S | Creon | Creon 10 | Creon 20 | Creon 5 | Dygase | Kutrase | Ku-Zyme | Ku-Zyme HP | Lapase | Lipram | Lipram-CR | Lipram-PN | Lipram-UL | Palcaps | Pancrease | Pancrease MT | Pancreaze | Pancrecarb MS | Pancron | Pangestyme CN | Pangestyme EC | Pangestyme MT | Pangestyme UL | Panocaps | Panocaps MT | Panokae-16 | Panokase | Pertzye | Plaretase | Ultracaps MT | Ultrase | Ultrase MT | Ultresa | Viokace | Viokase | Viokase 16 | Viokase 8 | Zenpep

What is Pancrelipase

Pancrelipase is an oral gastrointestinal agent. It is derived from porcine pancreatic enzymes and contains lipase, amylase, and protease, which are capable of digesting fats, starches, and proteins, respectively.

Pancrelipase has 12 times the lipolytic activity, 4 times the proteolytic activity, and 4 times the amylolytic activity of pancreatin.

Pancreatic enzyme replacement is usually reserved for patients with chronic pancreatic exocrine insufficiency; the enzymes help to re-establish the natural digestive conditions in the intestine and control steatorrhea.

Pancreatic insufficiency products are not clinically interchangeable and are not considered bioequivalent by the FDA.

Indications

  • cystic fibrosis
  • feeding tube occlusion
  • pancreatectomy
  • pancreatic insufficiency

Side Effects

  1. abdominal pain
  2. anaphylactoid reactions
  3. anemia
  4. ascites
  5. blurred vision
  6. bronchospasm
  7. cholecystitis
  8. cholelithiasis
  9. constipation
  10. cough
  11. diarrhea
  12. dizziness
  13. dyspepsia
  14. elevated hepatic enzymes
  15. epistaxis
  16. esophagitis
  17. fibrosing colonopathy
  18. flatulence
  19. gastritis
  20. GI obstruction
  21. headache
  22. hyperglycemia
  23. hyperuricemia
  24. hypoglycemia
  25. infection
  26. lactose intolerance
  27. lymphadenopathy
  28. maculopapular rash
  29. muscle cramps
  30. myalgia
  31. nasal congestion
  32. nausea
  33. oral ulceration
  34. otalgia
  35. peripheral edema
  36. pharyngitis
  37. pruritus
  38. pruritus ani
  39. rash
  40. stomatitis
  41. urticaria
  42. vomiting

Monitoring Parameters

  • stool exam

Contraindications

  • breast-feeding
  • diabetes mellitus
  • dysphagia
  • esophageal stricture
  • fibrosing colonopathy
  • GI obstruction
  • gout
  • hyperuricemia
  • inflammatory bowel disease
  • porcine protein hypersensitivity
  • pregnancy
  • renal impairment
  • surgery
  • viral infection

Interactions

  • Alpha-glucosidase Inhibitors
  • Antacids
  • Aspirin, ASA; Citric Acid; Sodium Bicarbonate
  • Calcium Carbonate
  • Calcium Carbonate; Magnesium Hydroxide
  • Calcium Carbonate; Risedronate
  • Calcium Carbonate; Simethicone
  • Omeprazole; Sodium Bicarbonate
  • Sodium Bicarbonate

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