Oxiconazole Brand Name– Oxistat
What is Oxiconazole
Oxiconazole is an imidazole-type topical antifungal agent. Oxiconazole is available as both a cream and lotion formulation.
The products contain 10 mg oxiconazole nitrate per gram of either the cream or lotion vehicle.
Oxiconazole is active against a variety of organisms responsible for causing tinea pedis, tinea corporis, and tinea cruris; the cream is also indicated to treat tinea versicolor.
Oxiconazole cream was FDA-approved in December 1988, and the lotion in September 1992.
Indications
- Candida albicans
- Epidermophyton floccosum
- Malassezia furfur
- Microsporum audouinii
- Microsporum canis
- Microsporum gypseum
- tinea corporis
- tinea cruris
- tinea pedis
- tinea versicolor
- Trichophyton mentagrophytes
- Trichophyton rubrum
- Trichophyton tonsurans
- Trichophyton violaceum
Side Effects
- contact dermatitis
- erythema
- folliculitis
- pruritus
- rash
- skin irritation
Topical administration of oxiconazole cream or lotion may be associated with local adverse effects which most commonly include pruritus (0.4—1.6%), burning (0.7—1.4%), stinging (0.1—0.7%), skin irritation (0.4%), allergic contact dermatitis (0.4%), folliculitis (0.3%), and erythema (0.2%). Other adverse effects observed in clinical trials that were attributed to drug therapy included papules, fissure, maceration, rash (unspecified), and nodules (0.1% each). Scaling, tingling, pain, and dishidrotic eczema were reported at an incidence of 0.4% each.
Monitoring Parameters
- laboratory monitoring not necessary
Contraindications
- azole antifungals hypersensitivity
- breast-feeding
- ocular exposure
- onychomycosis
- ophthalmic administration
- pregnancy
- vaginal administration
Interactions
- Nystatin
Nystatin: (Moderate) The combination of oxiconazole and nystatin represents duplication of therapy whenever the drugs are used by similar routes and are usually avoided.
