Oxaliplatin

Oxaliplatin Brand Name– Eloxatin

What is Oxaliplatin

Oxaliplatin is an intravenous, non cell-cycle specific, platinum-based alkylating agent.

Unlike cisplatin or carboplatin, it is not associated with significant renal or auditory toxicity.

It contains a bulky carrier ligand (1,2-diaminocyclohexane [DACH] which is not present in either cisplatin or carboplatin, contributing to a lack of cross-resistance with these compounds.

Oxaliplatin is indicated for the treatment of colorectal cancer in combination with fluorouracil and leucovorin.

Acute or delayed neuropathy can occur; avoid the topical application of ice, as cold temperatures may exacerbate acute neuropathy.

Indications

1. biliary tract cancer
2. breast cancer
3. colorectal cancer
4. gastric cancer
5. head and neck cancer
6. mesothelioma
7. non-Hodgkin’s lymphoma (NHL)
8. ovarian cancer
9. pancreatic cancer
10. testicular cancer

For the treatment of colorectal cancer

for the adjuvant treatment of colorectal cancer, in combination with leucovorin and 5-fluorouracil (5-FU) (FLOX)

Side Effects

1. abdominal pain
2. abdominal pain
3. alopecia
4. anaphylactic shock
5. anaphylactoid reactions
6. anemia
7. anemia
8. angioedema
9. anorexia
10. anorexia
11. anxiety
12. anxiety
13. arthralgia
14. arthralgia
15. ascites
16. ataxia
17. back pain
18. back pain
19. bleeding
20. bleeding
21. bone pain
22. bradycardia
23. bronchospasm
24. chest pain (unspecified)
25. chest pain (unspecified)
26. colitis
27. conjunctivitis
28. constipation
29. constipation
30. cough
31. cough
32. cranial nerve palsies
33. dehydration
34. dehydration
35. depression
36. depression
37. diaphoresis
38. diaphoresis
39. diarrhea
40. diarrhea
41. dizziness
42. dysarthria
43. dysesthesia
44. dysgeusia
45. dysgeusia
46. dyspepsia
47. dyspepsia
48. dysphagia
49. dysphagia
50. dyspnea
51. dyspnea
52. dysuria
53. dysuria
54. edema
55. edema
56. elevated hepatic enzymes
57. elevated hepatic enzymes
58. encephalopathy
59. epistaxis
60. epistaxis
61. erythema
62. esophagitis
63. fatigue
64. fatigue
65. fever
66. fever
67. flatulence
68. flatulence
69. flushing
70. flushing
71. gastroesophageal reflux
72. gastroesophageal reflux
73. GI bleeding
74. GI obstruction
75. gingivitis
76. headache
77. hearing loss
78. hematuria
79. hematuria
80. hemolytic-uremic syndrome
81. hemoptysis
82. hemorrhoids
83. hiccups
84. hiccups
85. hot flashes
86. hyperbilirubinemia
87. hyperbilirubinemia
88. hyperglycemia
89. hyperglycemia
90. hypertension
91. hypoalbuminemia
92. hypoalbuminemia
93. hypocalcemia
94. hypocalcemia
95. hypoesthesia
96. hypokalemia
97. hypokalemia
98. hyponatremia
99. hyponatremia
100. hypotension
101. hypotension
102. hypoxia
103. ileus
104. increased urinary frequency
105. increased urinary frequency
106. infection
107. infection
108. injection site reaction
109. injection site reaction
110. insomnia
111. insomnia
112. interstitial lung disease
113. interstitial nephritis
114. intracranial bleeding
115. lacrimation
116. leukoencephalopathy
117. leukopenia
118. leukopenia
119. lymphopenia
120. lymphopenia
121. melena
122. myalgia
123. myalgia
124. nausea
125. nausea
126. neutropenia
127. neutropenia
128. new primary malignancy
129. ocular pain
130. optic neuritis
131. palmar-plantar erythrodysesthesia (hand and foot syndrome)
132. palmar-plantar erythrodysesthesia (hand and foot syndrome)
133. pancreatitis
134. paresthesias
135. paresthesias
136. peliosis hepatis
137. peripheral edema
138. peripheral edema
139. peripheral neuropathy
140. peripheral neuropathy
141. pharyngitis
142. pneumonitis
143. proctitis
144. prolonged bleeding time
145. pruritus
146. pulmonary fibrosis
147. purpura
148. QT prolongation
149. rash
150. rash
151. renal failure (unspecified)
152. renal tubular necrosis
153. rhabdomyolysis
154. rhinitis
155. seizures
156. serious hypersensitivity reactions or anaphylaxis
157. sinus tachycardia
158. sinusoidal obstruction syndrome (SOS)
159. stomatitis
160. stomatitis
161. syncope
162. tenesmus
163. thrombocytopenia
164. thrombocytopenia
165. thromboembolism
166. thromboembolism
167. thrombosis
168. thrombotic thrombocytopenic purpura (TTP)
169. tissue necrosis
170. torsade de pointes
171. urinary incontinence
172. urticaria
173. vaginal bleeding
174. veno-occlusive disease (VOD)
175. vertigo
176. visual impairment
177. visual impairment
178. vomiting
179. vomiting
180. weakness
181. weight loss
182. weight loss
183. xerosis
184. xerostomia
185. xerostomia

Monitoring Parameters

• CBC with differential
• LFTs
• pregnancy testing
• serum creatinine
• serum electrolytes

Contraindications

• anticoagulant therapy
• apheresis
• AV block
• bleeding
• bone marrow suppression
• bradycardia
• breast-feeding
• cardiomyopathy
• celiac disease
• children
• chronic lung disease (CLD)
• contraception requirements
• electrolyte imbalance
• encephalopathy
• females
• fever
• geriatric
• heart failure
• hepatic disease
• hepatotoxicity
• human immunodeficiency virus (HIV) infection
• hyperparathyroidism
• hypocalcemia
• hypokalemia
• hypomagnesemia
• hypothermia
• hypothyroidism
• infertility
• long QT syndrome
• male-mediated teratogenicity
• myocardial infarction
• myopathy
• neutropenia
• peripheral neuropathy
• pheochromocytoma
• platinum compound hypersensitivity
• pneumonitis
• pregnancy
• pregnancy testing
• pulmonary disease
• pulmonary fibrosis
• QT prolongation
• reproductive risk
• rhabdomyolysis
• rheumatoid arthritis
• serious hypersensitivity reactions or anaphylaxis
• sickle cell disease
• sleep deprivation
• stroke
• systemic lupus erythematosus (SLE)
• thrombocytopenia
• torsade de pointes

Interactions

• Aclidinium; Formoterol
• Albuterol
• Albuterol; Ipratropium
• Alfuzosin
• Amiodarone
• Amitriptyline
• Amitriptyline; Chlordiazepoxide
• Amoxicillin; Clarithromycin; Lansoprazole
• Amoxicillin; Clarithromycin; Omeprazole
• Anagrelide
• Apixaban
• Apomorphine
• Arformoterol
• Aripiprazole
• Arsenic Trioxide
• Artemether; Lumefantrine
• Asenapine
• Atomoxetine
• Azithromycin
• Bedaquiline
• Bictegravir; Emtricitabine; Tenofovir Alafenamide
• Bismuth Subcitrate Potassium; Metronidazole; Tetracycline
• Bismuth Subsalicylate; Metronidazole; Tetracycline
• Budesonide; Formoterol
• Buprenorphine
• Buprenorphine; Naloxone
• Ceritinib
• Chloroquine
• Chlorpromazine
• Cidofovir
• Ciprofloxacin
• Cisapride
• Citalopram
• Clarithromycin
• Clofazimine
• Clomipramine
• Clozapine
• Codeine; Phenylephrine; Promethazine
• Codeine; Promethazine
• Crizotinib
• Cyclosporine
• Dabigatran
• Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
• Dasatinib
• Degarelix
• Desflurane
• Desipramine
• Deutetrabenazine
• Dextromethorphan; Promethazine
• Dextromethorphan; Quinidine
• Disopyramide
• Dofetilide
• Dolasetron
• Dolutegravir; Rilpivirine
• Donepezil
• Donepezil; Memantine
• Doravirine; Lamivudine; Tenofovir disoproxil fumarate
• Doxepin
• Dronedarone
• Droperidol
• Edoxaban
• Efavirenz
• Efavirenz; Emtricitabine; Tenofovir
• Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
• Eliglustat
• Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
• Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
• Emtricitabine; Rilpivirine; Tenofovir alafenamide
• Emtricitabine; Rilpivirine; Tenofovir disoproxil fumarate
• Emtricitabine; Tenofovir alafenamide
• Emtricitabine; Tenofovir disoproxil fumarate
• Encorafenib
• Enflurane
• Entrectinib
• Eribulin
• Erythromycin
• Erythromycin; Sulfisoxazole
• Escitalopram
• Ezogabine
• Fingolimod
• Flecainide
• Fluconazole
• Fluoxetine
• Fluoxetine; Olanzapine
• Fluphenazine
• Fluticasone; Salmeterol
• Fluticasone; Umeclidinium; Vilanterol
• Fluticasone; Vilanterol
• Fluvoxamine
• Formoterol
• Formoterol; Mometasone
• Foscarnet
• Gadoterate meglumine
• Gemifloxacin
• Gemtuzumab Ozogamicin
• Gilteritinib
• Glasdegib
• Glycopyrrolate; Formoterol
• Goserelin
• Granisetron
• Halogenated Anesthetics
• Haloperidol
• Halothane
• Histrelin
• Hydroxychloroquine
• Hydroxyzine
• Ibutilide
• Iloperidone
• Imipramine
• Indacaterol
• Indacaterol; Glycopyrrolate
• Inotuzumab Ozogamicin
• Iodipamide Meglumine
• Iohexol
• Ionic Contrast Media
• Iopamidol
• Iopromide
• Ioversol
• Ioxaglate Meglumine; Ioxaglate Sodium
• Isoflurane
• Isosulfan Blue
• Itraconazole
• Ivosidenib
• Kanamycin
• Ketoconazole
• Lamivudine; Tenofovir Disoproxil Fumarate
• Lapatinib
• Lefamulin
• Lenvatinib
• Leuprolide
• Leuprolide; Norethindrone
• Levalbuterol
• Levofloxacin
• Lithium
• Lofexidine
• Long-acting beta-agonists
• Loperamide
• Loperamide; Simethicone
• Lopinavir; Ritonavir
• Macimorelin
• Maprotiline
• Mefloquine
• Meperidine; Promethazine
• Metaproterenol
• Methadone
• Methotrexate
• Metronidazole
• Midostaurin
• Mifepristone
• Mirtazapine
• Moxifloxacin
• Nilotinib
• Non-Ionic Contrast Media
• Norfloxacin
• Nortriptyline
• Octreotide
• Ofloxacin
• Olanzapine
• Olodaterol
• Ondansetron
• Osilodrostat
• Osimertinib
• Ozanimod
• Palifermin
• Paliperidone
• Panobinostat
• Pasireotide
• Pazopanib
• Penicillamine
• Pentamidine
• Perphenazine
• Perphenazine; Amitriptyline
• Phenylephrine; Promethazine
• Pimavanserin
• Pimozide
• Pirbuterol
• Pitolisant
• Posaconazole
• Primaquine
• Procainamide
• Prochlorperazine
• Promethazine
• Propafenone
• Protriptyline
• Quetiapine
• Quinidine
• Quinine
• Ranolazine
• Ribociclib
• Ribociclib; Letrozole
• Rilpivirine
• Risperidone
• Rivaroxaban
• Romidepsin
• Salmeterol
• Saquinavir
• Selpercatinib
• Sertraline
• Sevoflurane
• Short-acting beta-agonists
• Siponimod
• Solifenacin
• Sorafenib
• Sotalol
• Sunitinib
• Tacrolimus
• Tamoxifen
• Telavancin
• Telithromycin
• Tenofovir Alafenamide
• Tenofovir Alafenamide
• Tenofovir, PMPA
• Terbutaline
• Tetrabenazine
• Thioridazine
• Tiotropium; Olodaterol
• Tolterodine
• Toremifene
• Trazodone
• Triclabendazole
• Tricyclic antidepressants
• Trifluoperazine
• Trimipramine
• Triptorelin
• Tuberculin Purified Protein Derivative, PPD
• Umeclidinium; Vilanterol
• Valacyclovir
• Vancomycin
• Vandetanib
• Vardenafil
• Vemurafenib
• Venlafaxine
• Voriconazole
• Vorinostat
• Warfarin
• Ziprasidone