Norfloxacin

Norfloxacin Brand Names- Chibroxin | Noroxin

What is Norfloxacin

Norfloxacin is an oral fluoroquinolone antibacterial agent. Norfloxacin has the shortest half-life of all currently available fluoroquinolones.

Disabling and potentially irreversible serious adverse reactions associated with quinolones include tendinitis, tendon rupture, peripheral neuropathy, and central nervous system effects.

Other significant adverse events include potential QT prolongation and myasthenia gravis exacerbation.

Due to norfloxacin’s relatively poor oral bioavailability, its clinical use is limited to the treatment of urinary tract infections (UTIs) and uncomplicated gonorrhea. However, due to the potential for serious adverse events, quinolones should only be used for UTIs when alternative treatment options cannot be used.

Norfloxacin was FDA-approved in October 1986.

Indications

1. bacterial conjunctivitis
2. bacterial infection prophylaxis
3. cervicitis
4. cystitis
5. gastroenteritis
6. gonorrhea
7. prostatitis
8. typhoid fever
9. urethritis
10. urinary tract infection (UTI)

Side Effects

1. abdominal pain
2. acute generalized exanthematous pustulosis (AGEP)
3. agitation
4. agranulocytosis
5. anemia
6. angioedema
7. anorexia
8. anxiety
9. aortic dissection
10. aplastic anemia
11. arthralgia
12. asthenia
13. ataxia
14. azotemia
15. back pain
16. blurred vision
17. candidiasis
18. chest pain (unspecified)
19. chills
20. cholestasis
21. coma
22. confusion
23. constipation
24. crystalluria
25. cylindruria
26. delirium
27. depression
28. diarrhea
29. diplopia
30. dizziness
31. drowsiness
32. Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS)
33. dysgeusia
34. dysmenorrhea
35. dyspepsia
36. dysphagia
37. dyspnea
38. edema
39. elevated hepatic enzymes
40. erythema
41. erythema multiforme
42. exfoliative dermatitis
43. fever
44. flatulence
45. glycosuria
46. Guillain-Barre syndrome
47. hallucinations
48. headache
49. hearing loss
50. hematuria
51. hemolytic anemia
52. hepatic failure
53. hepatic necrosis
54. hepatitis
55. hypercholesterolemia
56. hyperglycemia
57. hyperhidrosis
58. hyperkalemia
59. hypertriglyceridemia
60. hypoesthesia
61. hypoglycemia
62. increased intracranial pressure
63. insomnia
64. interstitial nephritis
65. jaundice
66. leukopenia
67. memory impairment
68. myalgia
69. myasthenia gravis
70. myocardial infarction
71. nausea
72. nephrolithiasis
73. neurotoxicity
74. neutropenia
75. nightmares
76. nystagmus
77. orthostatic hypotension
78. palpitations
79. pancreatitis
80. pancytopenia
81. paranoia
82. paresthesias
83. peripheral neuropathy
84. photosensitivity
85. pneumonitis
86. proteinuria
87. pruritus
88. pruritus ani
89. pseudomembranous colitis
90. pseudotumor cerebri
91. psychosis
92. pyrosis (heartburn)
93. QT prolongation
94. rash
95. renal failure (unspecified)
96. restlessness
97. seizures
98. serum sickness
99. Stevens-Johnson syndrome
100. stomatitis
101. suicidal ideation
102. superinfection
103. tendinitis
104. tendon rupture
105. thrombocytopenia
106. thrombotic thrombocytopenic purpura (TTP)
107. tinnitus
108. torsade de pointes
109. toxic epidermal necrolysis
110. tremor
111. urticaria
112. vasculitis
113. vomiting
114. xerostomia

Monitoring Parameters

• serum creatinine/BUN

Contraindications

• aneurysm
• aortic dissection
• apheresis
• arteriosclerosis
• atrial fibrillation
• AV block
• bradycardia
• breast-feeding
• cardiomyopathy
• celiac disease
• cerebrovascular disease
• children
• colitis
• corticosteroid therapy
• dehydration
• diabetes mellitus
• diarrhea
• driving or operating machinery
• females
• fever
• G6PD deficiency
• geriatric
• GI disease
• heart failure
• hepatic disease
• hepatitis
• hepatotoxicity
• human immunodeficiency virus (HIV) infection
• hyperparathyroidism
• hypertension
• hypocalcemia
• hypokalemia
• hypomagnesemia
• hypothermia
• hypothyroidism
• infants
• inflammatory bowel disease
• jaundice
• long QT syndrome
• myasthenia gravis
• myocardial infarction
• neonates
• neurotoxicity
• organ transplant
• peripheral neuropathy
• pheochromocytoma
• pregnancy
• pseudomembranous colitis
• psychiatric event
• QT prolongation
• quinolone hypersensitivity
• renal failure
• renal impairment
• rheumatoid arthritis
• seizures
• sexually transmitted disease
• sickle cell disease
• sleep deprivation
• stroke
• sunlight (UV) exposure
• systemic lupus erythematosus (SLE)
• tendinitis
• tendinopathy
• tendon pain
• tendon rupture
• torsade de pointes
• ulcerative colitis
• viral infection

Interactions

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