Nitrous Oxide (dinitrogen monoxide)

What is Nitrous Oxide

Nitrous oxide (dinitrogen monoxide) is a colorless, odorless, tasteless, nonflammable, nonirritating, inorganic gas used for general anesthesia.

Nitrous oxide is a powerful analgesic, but it is a relatively weak inhalational anesthetic and usually must be supplemented by other agents if general anesthesia is desired.

It is used in low doses to provide analgesia in obstetrics and during procedures that do not require unconsciousness.

Indications

  • dental anesthesia
  • general anesthesia induction
  • general anesthesia maintenance
  • procedural sedation
  • severe pain

For use in general anesthesia induction and general anesthesia maintenance

Side Effects

  1. anemia
  2. delirium
  3. hypoxia
  4. increased intracranial pressure
  5. leukopenia
  6. nausea
  7. respiratory depression
  8. shivering
  9. vomiting

Monitoring Parameters

  • arterial blood gases (ABGs)

Contraindications

  • air embolism
  • breast-feeding
  • GI obstruction
  • head trauma
  • hypoxemia
  • ileus
  • increased intracranial pressure
  • intracranial mass
  • middle ear cysts
  • pneumoencephalography
  • pneumothorax
  • pregnancy
  • pulmonary cysts
  • renal cysts

Use with caution during pregnancy because animal studies reveal nitrous oxide can cause fetal death, growth retardation, and skeletal anomalies.

Interactions

No information is available regarding drug interactions associated with Nitrous Oxide 

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