Niraparib

Niraparib Brand Name– ZEJULA

What is Niraparib

Niraparib is an oral poly (ADP-ribose) polymerase (PARP) inhibitor. PARP enzymes are involved in normal cellular homeostasis, including DNA transcription, cell cycle regulation, and DNA repair.

It is indicated as maintenance therapy in patients with platinum-sensitive epithelial ovarian, fallopian tube, or primary peritoneal cancer, as well as monotherapy for patients with heavily pretreated, advanced epithelial ovarian, fallopian tube, or primary peritoneal cancer in patients with associated homologous recombination deficiency (HRD) positive status.

Niraparib has been associated with hematologic toxicity; cases of myelodysplastic syndrome (MDS) or acute myeloid leukemia (AML) have also been reported. Complete blood counts should be closely monitored.

Indications

• ovarian cancer

For the treatment of ovarian cancer

for the first-line maintenance therapy of advanced epithelial ovarian, fallopian tube, or primary peritoneal cancer in patients who are in a complete or partial response to first-line platinum-based chemotherapy, as monotherapy

Side Effects

1. abdominal pain
2. abdominal pain
3. anaphylactoid reactions
4. anemia
5. anemia
6. anorexia
7. anorexia
8. anxiety
9. anxiety
10. asthenia
11. asthenia
12. back pain
13. back pain
14. confusion
15. conjunctivitis
16. constipation
17. constipation
18. cough
19. depression
20. diarrhea
21. diarrhea
22. dizziness
23. dysgeusia
24. dyspepsia
25. dyspnea
26. dyspnea
27. elevated hepatic enzymes
28. elevated hepatic enzymes
29. encephalopathy
30. epistaxis
31. fatigue
32. fatigue
33. GI obstruction
34. GI perforation
35. hallucinations
36. headache
37. headache
38. hyperglycemia
39. hyperglycemia
40. hypertension
41. hypertension
42. hypertensive crisis
43. hypoalbuminemia
44. hypoalbuminemia
45. hypokalemia
46. hypomagnesemia
47. hypomagnesemia
48. hyponatremia
49. hyponatremia
50. impaired cognition
51. infection
52. infection
53. insomnia
54. insomnia
55. leukemia
56. leukopenia
57. leukopenia
58. lymphopenia
59. musculoskeletal pain
60. musculoskeletal pain
61. nausea
62. nausea
63. neutropenia
64. neutropenia
65. new primary malignancy
66. palpitations
67. peripheral edema
68. pharyngitis
69. photosensitivity
70. pleural effusion
71. pneumonitis
72. rash
73. rash
74. renal failure (unspecified)
75. sinus tachycardia
76. stomatitis
77. stomatitis
78. thrombocytopenia
79. thrombocytopenia
80. vomiting
81. vomiting
82. weight loss
83. xerostomia
84. xerostomia

Monitoring Parameters

• blood pressure
• CBC with differential
• heart rate
• pregnancy testing

Contraindications

• anemia
• bone marrow suppression
• breast-feeding
• cardiac arrhythmias
• cardiac disease
• contraception requirements
• heart failure
• hypertension
• hypertensive crisis
• infertility
• leukemia
• myelodysplastic syndrome (MDS)
• neutropenia
• new primary malignancy
• pregnancy
• pregnancy testing
• reproductive risk
• thrombocytopenia

Interactions

There are no drug interactions associated with Niraparib products.