Nesiritide BNP

Nesiritide BNP Brand Name– Natrecor

What is Nesiritide BNP

Nesiritide is an intravenous recombinant purified preparation of human B-type natriuretic peptide (hBNP), a naturally-occurring hormone produced in the ventricles of the heart. The drug is produced in E. coli using recombinant DNA technology.

Nesiritide is indicated for the acute treatment of decompensated congestive heart failure (CHF), and has primarily been studied in patients with elevated pulmonary capillary wedge pressure (PCWP) more than 18 to 20 mmHg.

In decompensated heart failure, the use of nesiritide reduces PCWP and has been shown to improve the symptoms of heart failure, including global clinical status, dyspnea, and fatigue.

The overall safety of nesiritide has been questioned based on the results of two publications which have reported an increased risk of worsening renal function and a trend toward increased mortality in nesiritide-treated patients versus placebo.

Indications

  • heart failure

For the treatment of acutely decompensated congestive heart failure in patients who have dyspnea at rest or with minimal activity

Side Effects

  1. abdominal pain
  2. amblyopia
  3. anemia
  4. angina
  5. anxiety
  6. apnea
  7. atrial fibrillation
  8. azotemia
  9. back pain
  10. bradycardia
  11. confusion
  12. cough
  13. diaphoresis
  14. dizziness
  15. drowsiness
  16. fever
  17. headache
  18. hemoptysis
  19. hypoglycemia
  20. hypotension
  21. injection site reaction
  22. insomnia
  23. muscle cramps
  24. nausea
  25. orthostatic hypotension
  26. paresthesias
  27. premature ventricular contractions (PVCs)
  28. pruritus
  29. rash
  30. renal failure (unspecified)
  31. sinus tachycardia
  32. syncope
  33. tremor
  34. ventricular tachycardia
  35. vomiting

Monitoring Parameters

  • serum creatinine/BUN
  • weight

Contraindications

  • aortic stenosis
  • atrial fibrillation
  • atrial flutter
  • breast-feeding
  • cardiac arrhythmias
  • cardiac disease
  • cardiogenic shock
  • cardiomyopathy
  • cerebrovascular disease
  • children
  • constrictive pericarditis
  • coronary artery disease
  • E. coli protein hypersensitivity
  • geriatric
  • hypotension
  • hypovolemia
  • idiopathic hypertrophic subaortic stenosis
  • infants
  • mitral stenosis
  • neonates
  • orthostatic hypotension
  • pericardial effusion
  • pregnancy
  • renal disease
  • renal failure
  • renal impairment
  • respiratory depression
  • valvular heart disease
  • ventricular arrhythmias

Interactions

  • Acetaminophen; Butalbital; Caffeine; Codeine
  • Acetaminophen; Caffeine; Dihydrocodeine
  • Acetaminophen; Codeine
  • Acetaminophen; Hydrocodone
  • Acetaminophen; Oxycodone
  • Acetaminophen; Propoxyphene
  • Alfentanil
  • Alpha-blockers
  • Amyl Nitrite
  • Angiotensin II receptor antagonists
  • Angiotensin-converting enzyme inhibitors
  • Articaine; Epinephrine
  • Aspirin, ASA; Butalbital; Caffeine; Codeine
  • Aspirin, ASA; Caffeine; Dihydrocodeine
  • Aspirin, ASA; Carisoprodol; Codeine
  • Aspirin, ASA; Oxycodone
  • Belladonna; Opium
  • Beta-adrenergic blockers
  • Brompheniramine; Guaifenesin; Hydrocodone
  • Brompheniramine; Hydrocodone; Pseudoephedrine
  • Calcium-channel blockers
  • Carbinoxamine; Hydrocodone; Phenylephrine
  • Carbinoxamine; Hydrocodone; Pseudoephedrine
  • Cardiac glycosides
  • Central-acting adrenergic agents
  • Chlorpheniramine; Codeine
  • Chlorpheniramine; Dihydrocodeine; Phenylephrine
  • Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
  • Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Hydrocodone
  • Chlorpheniramine; Hydrocodone; Phenylephrine
  • Chlorpheniramine; Hydrocodone; Pseudoephedrine
  • Codeine
  • Codeine; Guaifenesin
  • Codeine; Phenylephrine; Promethazine
  • Codeine; Promethazine
  • Dexmedetomidine
  • Dihydrocodeine; Guaifenesin; Pseudoephedrine
  • Diphenhydramine; Hydrocodone; Phenylephrine
  • Dobutamine
  • Dopamine
  • Epinephrine
  • Eplerenone
  • Epoprostenol
  • Fentanyl
  • General anesthetics
  • Ginger, Zingiber officinale
  • Guaifenesin; Hydrocodone
  • Guaifenesin; Hydrocodone; Pseudoephedrine
  • Homatropine; Hydrocodone
  • Hydralazine; Isosorbide Dinitrate, ISDN
  • Hydrocodone
  • Hydrocodone; Ibuprofen
  • Hydrocodone; Phenylephrine
  • Hydrocodone; Potassium Guaiacolsulfonate
  • Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
  • Hydrocodone; Pseudoephedrine
  • Hydromorphone
  • Ibuprofen; Oxycodone
  • Iloprost
  • Isoproterenol
  • Isosorbide Dinitrate, ISDN
  • Isosorbide Mononitrate
  • Levorphanol
  • Loop diuretics
  • Mecamylamine
  • Meperidine
  • Meperidine; Promethazine
  • Methadone
  • Methohexital
  • Morphine
  • Morphine; Naltrexone
  • Nitrates
  • Nitroglycerin
  • Opiate Agonists
  • Oxycodone
  • Oxymorphone
  • Potassium-sparing diuretics
  • Prilocaine; Epinephrine
  • Propoxyphene
  • Remifentanil
  • Reserpine
  • Sildenafil
  • Sufentanil
  • Thiazide diuretics
  • Thiopental
  • Treprostinil
  • Vasodilators
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