Nebivolol and Valsartan

Nebivolol and Valsartan Brand Name– BYVALSON

What is Nebivolol and Valsartan

Nebivolol and valsartan is an oral beta-blocker and angiotensin II receptor blocker (ARB) combination medication for the treatment of hypertension.

Nebivolol is a beta-1 selective (cardioselective) adrenergic antagonist.

Unlike propranolol, which nonspecifically blocks beta-1 and beta-2 adrenoreceptors, or atenolol, which has more affinity for the beta-1 adrenoreceptor but at higher doses loses its beta-1 specificity, nebivolol has an even higher affinity for the beta-1 adrenoreceptor at therapeutic doses.

Valsartan is a specific angiotensin II antagonist which selectively and competitively blocks the AT-1 receptor, which mediates the vasopressor and aldosterone effects of angiotensin II.

The combination product is indicated as initial therapy in patients not adequately controlled on valsartan 80 mg or nebivolol up to and including 10 mg and also can be substituted in patients already receiving 5 mg nebivolol and 80 mg valsartan.

Nebivolol and valsartan was FDA-approved in June 2016.

Indications

  • hypertension

Side Effects

  1. alopecia
  2. angioedema
  3. AV block
  4. bronchospasm
  5. drowsiness
  6. elevated hepatic enzymes
  7. hepatitis
  8. hyperbilirubinemia
  9. hyperkalemia
  10. hypotension
  11. impotence (erectile dysfunction)
  12. myocardial infarction
  13. pruritus
  14. psoriasis
  15. pulmonary edema
  16. rash
  17. renal failure (unspecified)
  18. syncope
  19. teratogenesis
  20. thrombocytopenia
  21. urticaria
  22. vasculitis
  23. vertigo
  24. vomiting

Monitoring Parameters

  • blood pressure
  • heart rate
  • LFTs
  • serum creatinine
  • serum potassium

Contraindications

  • abrupt discontinuation
  • acute bronchospasm
  • AV block
  • bradycardia
  • breast-feeding
  • cardiogenic shock
  • diabetes mellitus
  • heart failure
  • hepatic disease
  • hyperkalemia
  • hyperthyroidism
  • hypoglycemia
  • hypotension
  • peripheral vascular disease
  • pheochromocytoma
  • pregnancy
  • renal impairment
  • sick sinus syndrome
  • surgery
  • thyrotoxicosis

Interactions

  • Abiraterone
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  • Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
  • Acetaminophen; Dextromethorphan; Phenylephrine
  • Acetaminophen; Dextromethorphan; Pseudoephedrine
  • Acetaminophen; Dichloralphenazone; Isometheptene
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