Naratriptan

Naratriptan Brand Name– Amerge

What is Naratriptan

Naratriptan is an antimigraine agent similar to sumatriptan but with a longer half life and a corresponding longer duration of action.

In clinical trials, naratriptan had a slower onset and was slightly less effective than sumatriptan, but naratriptan was better tolerated. In addition, migraine recurrence was lower with naratriptan.

Naratriptan is approved for the acute treatment of migraine attacks with or without aura in adults, and may be used off-label for menstrual migraine prophylaxis.

Naratriptan oral tablets were approved for marketing on February 10, 1998.

Indications

• menstrual migraine prophylaxis
• migraine

For the acute treatment of migraine with or without aura

NOTE: Naratriptan is not indicated for hemiplegic or basilar migraine.

Side Effects

1. abdominal pain
2. acne vulgaris
3. agitation
4. alopecia
5. anaphylactoid reactions
6. anemia
7. angina
8. angioedema
9. anxiety
10. aphasia
11. arrhythmia exacerbation
12. arthralgia
13. atrial fibrillation
14. atrial flutter
15. blurred vision
16. bone pain
17. bowel ischemia
18. bradycardia
19. breast discharge
20. bronchospasm
21. chest pain (unspecified)
22. chest pressure syndrome
23. chills
24. colitis
25. confusion
26. constipation
27. coronary vasospasm
28. cough
29. cystitis
30. dehydration
31. depression
32. diarrhea
33. diuresis
34. dizziness
35. drowsiness
36. dysgeusia
37. dyspepsia
38. dyspnea
39. edema
40. elevated hepatic enzymes
41. erythema
42. esophagitis
43. fatigue
44. fever
45. fluid retention
46. folliculitis
47. gastritis
48. gastroesophageal reflux
49. glycosuria
50. hallucinations
51. headache
52. hearing loss
53. hemorrhoids
54. hostility
55. hypercholesterolemia
56. hyperesthesia
57. hyperglycemia
58. hyperhidrosis
59. hyperlipidemia
60. hypertension
61. hypertensive crisis
62. hyperthermia
63. hypoesthesia
64. hypotension
65. hypothyroidism
66. impaired cognition
67. infection
68. intracranial bleeding
69. libido decrease
70. malaise
71. muscle cramps
72. musculoskeletal pain
73. myalgia
74. myocardial infarction
75. nausea
76. neuritis
77. ocular hemorrhage
78. ocular pain
79. palpitations
80. paresthesias
81. peptic ulcer
82. peripheral vasoconstriction
83. photophobia
84. photosensitivity
85. polydipsia
86. polyuria
87. PR prolongation
88. premature ventricular contractions (PVCs)
89. proteinuria
90. pruritus
91. purpura
92. QT prolongation
93. rash
94. rhinitis
95. scotomata
96. seizures
97. serotonin syndrome
98. sialadenitis
99. sinusitis
100. ST-T wave changes
101. stroke
102. syncope
103. thrombocytopenia
104. tinnitus
105. tracheitis
106. tremor
107. urinary incontinence
108. urinary urgency
109. urticaria
110. ventricular fibrillation
111. ventricular tachycardia
112. vertigo
113. visual impairment
114. vomiting
115. withdrawal
116. xerophthalmia
117. xerosis

Monitoring Parameters

• ECG

Contraindications

• acute myocardial infarction
• angina
• arteriosclerosis
• basilar/hemiplegic migraine
• breast-feeding
• cardiac arrhythmias
• cardiac disease
• cerebrovascular disease
• colitis
• coronary artery disease
• diabetes mellitus
• driving or operating machinery
• geriatric
• hepatic disease
• hypercholesterolemia
• hypertension
• intracranial bleeding
• myocardial infarction
• obesity
• peripheral vascular disease
• pregnancy
• renal failure
• renal impairment
• stroke
• tobacco smoking
• vasospastic angina
• Wolff-Parkinson-White syndrome

Interactions

• Acetaminophen; Butalbital; Caffeine; Codeine
• Acetaminophen; Caffeine; Dihydrocodeine
• Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
• Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
• Acetaminophen; Codeine
• Acetaminophen; Dextromethorphan
• Acetaminophen; Dextromethorphan; Doxylamine
• Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
• Acetaminophen; Dextromethorphan; Phenylephrine
• Acetaminophen; Dextromethorphan; Pseudoephedrine
• Acetaminophen; Hydrocodone
• Acetaminophen; Oxycodone
• Acetaminophen; Tramadol
• Alfentanil
• Almotriptan
• Amitriptyline
• Amitriptyline; Chlordiazepoxide
• Amphetamine
• Amphetamine; Dextroamphetamine
• Amphetamine; Dextroamphetamine Salts
• Aspirin, ASA; Butalbital; Caffeine; Codeine
• Aspirin, ASA; Caffeine; Dihydrocodeine
• Aspirin, ASA; Carisoprodol; Codeine
• Aspirin, ASA; Oxycodone
• Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
• Benzhydrocodone; Acetaminophen
• Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
• Benzphetamine
• Bromocriptine
• Brompheniramine; Dextromethorphan; Guaifenesin
• Brompheniramine; Dextromethorphan; Phenylephrine
• Brompheniramine; Guaifenesin; Hydrocodone
• Brompheniramine; Hydrocodone; Pseudoephedrine
• Buprenorphine
• Buprenorphine; Naloxone
• Buspirone
• Carbinoxamine; Dextromethorphan; Pseudoephedrine
• Carbinoxamine; Hydrocodone; Phenylephrine
• Carbinoxamine; Hydrocodone; Pseudoephedrine
• Chlorpheniramine; Codeine
• Chlorpheniramine; Dextromethorphan
• Chlorpheniramine; Dextromethorphan; Phenylephrine
• Chlorpheniramine; Dihydrocodeine; Phenylephrine
• Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
• Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
• Chlorpheniramine; Hydrocodone
• Chlorpheniramine; Hydrocodone; Phenylephrine
• Chlorpheniramine; Hydrocodone; Pseudoephedrine
• Citalopram
• Clomipramine
• Cocaine
• Codeine
• Codeine; Guaifenesin
• Codeine; Phenylephrine; Promethazine
• Codeine; Promethazine
• Desipramine
• Desvenlafaxine
• Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
• Dextroamphetamine
• Dextromethorphan
• Dextromethorphan; Diphenhydramine; Phenylephrine
• Dextromethorphan; Guaifenesin
• Dextromethorphan; Guaifenesin; Phenylephrine
• Dextromethorphan; Guaifenesin; Potassium Guaiacolsulfonate
• Dextromethorphan; Guaifenesin; Pseudoephedrine
• Dextromethorphan; Promethazine
• Dextromethorphan; Quinidine
• Dihydrocodeine; Guaifenesin; Pseudoephedrine
• Diphenhydramine; Hydrocodone; Phenylephrine
• Doxepin
• Drospirenone; Ethinyl Estradiol
• Drospirenone; Ethinyl Estradiol; Levomefolate
• Droxidopa
• Duloxetine
• Eletriptan
• Ergot alkaloids
• Escitalopram
• Ethinyl Estradiol
• Ethinyl Estradiol; Desogestrel
• Ethinyl Estradiol; Ethynodiol Diacetate
• Ethinyl Estradiol; Etonogestrel
• Ethinyl Estradiol; Levonorgestrel
• Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate
• Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
• Ethinyl Estradiol; Norelgestromin
• Ethinyl Estradiol; Norethindrone
• Ethinyl Estradiol; Norethindrone Acetate
• Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
• Ethinyl Estradiol; Norethindrone; Ferrous fumarate
• Ethinyl Estradiol; Norgestimate
• Ethinyl Estradiol; Norgestrel
• Fenfluramine
• Fentanyl
• Fluoxetine
• Fluoxetine; Olanzapine
• Fluvoxamine
• Frovatriptan
• Guaifenesin; Hydrocodone
• Guaifenesin; Hydrocodone; Pseudoephedrine
• Homatropine; Hydrocodone
• Hydrocodone
• Hydrocodone; Ibuprofen
• Hydrocodone; Phenylephrine
• Hydrocodone; Potassium Guaiacolsulfonate
• Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
• Hydrocodone; Pseudoephedrine
• Hydromorphone
• Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
• Ibuprofen; Oxycodone
• Imipramine
• Isocarboxazid
• Lasmiditan
• Levomilnacipran
• Levorphanol
• Linezolid
• Lisdexamfetamine
• Lithium
• Lorcaserin
• Meperidine
• Meperidine; Promethazine
• Methadone
• Methamphetamine
• Methenamine; Sodium Acid Phosphate; Methylene Blue; Hyoscyamine
• Methylene Blue
• Milnacipran
• Mirtazapine
• Morphine
• Morphine; Naltrexone
• Nalbuphine
• Naproxen; Sumatriptan
• Nefazodone
• Nortriptyline
• Oxycodone
• Oxymorphone
• Ozanimod
• Paroxetine
• Perphenazine; Amitriptyline
• Phenelzine
• Protriptyline
• Rasagiline
• Remifentanil
• Rizatriptan
• Safinamide
• Segesterone Acetate; Ethinyl Estradiol
• Selective serotonin reuptake inhibitors
• Selegiline
• Sertraline
• Sibutramine
• St. John’s Wort, Hypericum perforatum
• Sufentanil
• Sumatriptan
• Tapentadol
• Tedizolid
• tobacco
• Tramadol
• Tranylcypromine
• Trazodone
• Tricyclic antidepressants
• Trimipramine
• Venlafaxine
• Vilazodone
• Vortioxetine
• Zolmitriptan