Mometasone

Mometasone Brand Names

Asmanex | Asmanex HFA | Elocon | Nasonex | Propel | Propel Contour | SINUVA

What is Mometasone

Mometasone is a synthetic corticosteroid with anti-inflammatory, antipruritic, and vasoconstrictive properties; products are available in topical, nasal, and inhaled dosage forms.

Mometasone is used topically to relieve the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses and psoriasis. Most mometasone products are of medium-potency; however, the mometasone ointment is considered more potent.

Topical mometasone is resistant to metabolism in the skin, and repeated applications may lead to a depot effect and prolonged actions and an increased risk of systemic absorption.

Nasal topical sprays treat symptoms of perennial or seasonal allergic rhinitis, and sinus implants containing mometasone are used to reduce inflammation and the recurrence of nasal polyps following sinus surgery. Respiratory inhalations are used for the maintenance treatment of asthma.

For the treatment of asthma, the dry powder formulation has the advantage in that it can be given once daily, as opposed to the other ICSs that must be given twice daily.

Inhaled corticosteroids (ICSs) are the preferred pharmacologic treatment in the long-term management of asthma.

Maintenance ICS therapy may also decrease the frequency and severity of exercise-induced bronchoconstriction (EIB); short-acting beta-2 agonists (SABAs) also help prevent EIB but tolerance can develop with regular SABA use

Indications

1. allergic rhinitis
2. allergic rhinitis prophylaxis
3. alopecia
4. asthma
5. atopic dermatitis
6. contact dermatitis
7. discoid lupus erythematosus
8. eczema
9. exercise-induced bronchospasm prophylaxis
10. exfoliative dermatitis
11. granuloma annulare
12. keloids
13. lichen planus
14. lichen striatus
15. nasal congestion
16. nasal polyps
17. necrobiosis lipoidica diabeticorum
18. pemphigus
19. perennial allergies
20. pityriasis rosea
21. polymorphous light eruption
22. pruritus
23. psoriasis
24. Rhus dermatitis
25. sarcoidosis
26. seasonal allergies
27. seborrheic dermatitis
28. sinus patency maintenance
29. sinusitis
30. xerosis

Side Effects

1. abdominal pain
2. acneiform rash
3. adrenocortical insufficiency
4. anaphylactoid reactions
5. angioedema
6. anorexia
7. arthralgia
8. back pain
9. blurred vision
10. bronchospasm
11. candidiasis
12. cataracts
13. chest pain (unspecified)
14. conjunctivitis
15. contact dermatitis
16. cough
17. Cushing’s syndrome
18. depression
19. diarrhea
20. dysgeusia
21. dysmenorrhea
22. dyspepsia
23. dysphonia
24. dyspnea
25. epistaxis
26. erythema
27. fatigue
28. fever
29. folliculitis
30. foreign body sensation
31. furunculosis
32. glycosuria
33. growth inhibition
34. headache
35. hyperesthesia
36. hyperglycemia
37. hypertrichosis
38. hypothalamic-pituitary-adrenal (HPA) suppression
39. immunosuppression
40. impaired wound healing
41. increased intracranial pressure
42. infection
43. miliaria
44. musculoskeletal pain
45. myalgia
46. nasal congestion
47. nasal dryness
48. nasal irritation
49. nasal septum perforation
50. nausea
51. ocular hypertension
52. osteopenia
53. osteoporosis
54. otalgia
55. papilledema
56. paresthesias
57. parosmia
58. pharyngitis
59. pruritus
60. purpura
61. rash
62. retinopathy
63. rhinitis
64. sinusitis
65. skin atrophy
66. skin hypopigmentation
67. skin irritation
68. skin ulcer
69. striae
70. telangiectasia
71. throat irritation
72. toxic-shock syndrome
73. visual impairment
74. vomiting
75. wheezing
76. withdrawal
77. xerosis
78. xerostomia

Monitoring Parameters

• pulmonary function tests (PFTs)

Contraindications

• abrupt discontinuation
• acne rosacea
• acne vulgaris
• acute bronchospasm
• adrenal insufficiency
• breast-feeding
• cataracts
• children
• corticosteroid hypersensitivity
• Cushing’s syndrome
• diabetes mellitus
• fungal infection
• geriatric
• glaucoma
• growth inhibition
• hepatic disease
• herpes infection
• hyperglycemia
• hypothalamic-pituitary-adrenal (HPA) suppression
• increased intracranial pressure
• increased intraocular pressure
• infants
• infection
• measles
• milk protein hypersensitivity
• nasal septal perforation
• nasal surgery
• nasal trauma
• neonates
• occlusive dressing
• ocular exposure
• osteoporosis
• paradoxical bronchospasm
• perioral dermatitis
• peripheral vascular disease
• pregnancy
• skin abrasion
• skin atrophy
• status asthmaticus
• sunlight (UV) exposure
• surgery
• tuberculosis
• varicella
• viral infection
• visual disturbance

Interactions

• Abatacept
• Acetaminophen; Aspirin, ASA; Caffeine
• Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
• Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
• Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
• Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
• Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
• Acetaminophen; Dextromethorphan; Phenylephrine
• Acetaminophen; Guaifenesin; Phenylephrine
• Acetazolamide
• Acetohexamide
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• Aldesleukin, IL-2
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• Alogliptin; Metformin
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• Ambenonium Chloride
• Amifampridine
• Amiloride; Hydrochlorothiazide, HCTZ
• Aminolevulinic Acid
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• Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
• Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
• Amoxicillin; Clarithromycin; Lansoprazole
• Amoxicillin; Clarithromycin; Omeprazole
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• Aspirin, ASA; Caffeine; Dihydrocodeine
• Aspirin, ASA; Caffeine; Orphenadrine
• Aspirin, ASA; Carisoprodol
• Aspirin, ASA; Carisoprodol; Codeine
• Aspirin, ASA; Citric Acid; Sodium Bicarbonate
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• grapefruit juice
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