Mogamulizumab Brand Name– POTELIGEO
What is Mogamulizumab
Mogamulizumab-kpkc is a CC chemokine receptor type 4 (CCR4)-directed monoclonal antibody indicated for the treatment of adult patients with relapsed or refractory mycosis fungoides or Sezary syndrome after at least 1 prior systemic therapy.
Fatal and life-threatening skin reactions and infusion-related reactions have been reported with mogamulizumab therapy.
Indications
- cutaneous T-cell lymphoma (CTCL)
- mycosis fungoides
For the treatment of cutaneous T-cell lymphoma (CTCL), specifically mycosis fungoides or sezary syndrome, in patients who have received at least 1 prior systemic therapy
NOTE: Mogamulizumab has been designated by the FDA as an orphan drug for the treatment of patients with CTCL.
Side Effects
- abdominal pain
- alopecia
- anemia
- anemia
- anorexia
- antibody formation
- atopic dermatitis
- atopic dermatitis
- back pain
- back pain
- bone pain
- bone pain
- bullous rash
- bullous rash
- candidiasis
- cardiomyopathy
- chills
- conjunctivitis
- constipation
- contact dermatitis
- contact dermatitis
- cough
- depression
- diarrhea
- dizziness
- dyspnea
- edema
- elevated hepatic enzymes
- elevated hepatic enzymes
- exfoliative dermatitis
- fatigue
- fever
- fever
- folliculitis
- graft-versus-host disease (GVHD)
- Guillain-Barre syndrome
- headache
- heart failure
- hepatitis
- hepatitis B exacerbation
- hypercalcemia
- hypercalcemia
- hyperglycemia
- hyperglycemia
- hypertension
- hyperuricemia
- hypoalbuminemia
- hypoalbuminemia
- hypocalcemia
- hypocalcemia
- hypoglycemia
- hypomagnesemia
- hypomagnesemia
- hypophosphatemia
- hypophosphatemia
- hypothyroidism
- infection
- infection
- infusion-related reactions
- infusion-related reactions
- insomnia
- laryngitis
- leukopenia
- lymphopenia
- lymphopenia
- maculopapular rash
- maculopapular rash
- muscle cramps
- musculoskeletal pain
- musculoskeletal pain
- myalgia
- myalgia
- myocardial infarction
- myocarditis
- nausea
- nephrotoxicity
- neutropenia
- neutropenia
- oral ulceration
- oral ulceration
- peripheral neuropathy
- pharyngitis
- pneumonitis
- psoriaform rash
- rash
- rash
- rhinitis
- sinus tachycardia
- sinusitis
- skin ulcer
- skin ulcer
- Stevens-Johnson syndrome
- stomatitis
- stomatitis
- thrombocytopenia
- toxic epidermal necrolysis
- tumor lysis syndrome (TLS)
- vomiting
- weight gain
- weight loss
- xerosis
Monitoring Parameters
- pregnancy testing
Contraindications
- allogeneic stem cell transplant
- autoimmune disease
- breast-feeding
- contraception requirements
- immune-mediated reactions
- infection
- infusion-related reactions
- pregnancy
- pregnancy testing
- reproductive risk
- serious rash
Interactions
- Palifermin
- Penicillamine
- Tuberculin Purified Protein Derivative, PPD
