Miconazole

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Miconazole Brand Names

Aloe Vesta | Antifungal | AZOLEN TINCTURE | Baza | Cruex | Desenex | Desenex Jock Itch | Fungoid | Lotrimin AF | Lotrimin AF Antifungal Liquid | Lotrimin AF Deodorant | Lotrimin AF Powder | Lotrimin AF Spray | Micaderm | Micatin | Micro-Guard | Mitrazol | Monistat 1 Day or Night Combination Pack | Monistat 1 Vaginal Ovule Combination Pack | Monistat 1 Vaginal Ovule Combination Pack (Prefilled) | Monistat 3 | Monistat 3 Vaginal Cream (Prefilled) | Monistat 3 Vaginal Cream Combination Pack | Monistat 3 Vaginal Cream Combination Pack (Prefilled) | Monistat 3 Vaginal Ovule Combination Pack | Monistat 3 Vaginal Suppositories Combination Pack | Monistat 7 | Monistat 7 Vaginal Cream Combination Pack | Monistat-Derm | Neosporin AF | Novana Anti-Fungal | Oravig | Remedy | Soothe & Cool INZO | Ting Antifungal | Triple Paste AF | Vagistat-3 | Zeasorb Athlete’s Foot | Zeasorb Jock Itch

What is Miconazole

Miconazole is an imidazole-type antifungal.

When it was first approved, it was hoped it would replace amphotericin B as a parenteral antifungal agent. It was soon discovered, however, that miconazole not only failed to offer the same efficacy as amphotericin B, but it also possessed intrinsic toxicities after IV administration.

While miconazole is no longer marketed in a parenteral formulation in the US, it is still used topically and intravaginally for various fungal infections.

Miconazole was originally approved by the FDA in 1974.

A bioadhesive buccal tablet was approved by the FDA in April, 2010 for the local treatment of oropharyngeal candidiasis.

Indications

  1. Candida albicans
  2. Candida parapsilosis
  3. Candida sp.
  4. Candida tropicalis
  5. diaper dermatitis
  6. Epidermophyton floccosum
  7. mucocutaneous candidiasis
  8. oropharyngeal candidiasis (thrush)
  9. tinea corporis
  10. tinea cruris
  11. tinea pedis
  12. tinea versicolor
  13. Trichophyton mentagrophytes
  14. Trichophyton rubrum
  15. vulvovaginal candidiasis

Side Effects

  1. abdominal pain
  2. anaphylactoid reactions
  3. anemia
  4. cough
  5. diarrhea
  6. dysgeusia
  7. elevated hepatic enzymes
  8. fatigue
  9. fever
  10. headache
  11. infection
  12. lymphopenia
  13. nausea
  14. neutropenia
  15. oral ulceration
  16. pruritus
  17. rash
  18. skin irritation
  19. vaginal discharge
  20. vomiting
  21. xerostomia

Monitoring Parameters

  • laboratory monitoring not necessary

Contraindications

  • abdominal pain
  • azole antifungals hypersensitivity
  • breast-feeding
  • children
  • contraceptive devices
  • fever
  • hepatic disease
  • infants
  • menstruation
  • milk protein hypersensitivity
  • nausea/vomiting
  • neonates
  • ocular exposure
  • pregnancy
  • tobacco smoking
  • vaginal discharge

Miconazole is contraindicated in patients with known miconazole hypersensitivity.

Interactions

  • Acetohexamide
  • Belladonna Alkaloids; Ergotamine; Phenobarbital
  • Caffeine; Ergotamine
  • Chlorpropamide
  • Dihydroergotamine
  • Drospirenone; Ethinyl Estradiol
  • Drospirenone; Ethinyl Estradiol; Levomefolate
  • Ergoloid Mesylates
  • Ergonovine
  • Ergot alkaloids
  • Ergotamine
  • Ethinyl Estradiol
  • Ethinyl Estradiol; Desogestrel
  • Ethinyl Estradiol; Ethynodiol Diacetate
  • Ethinyl Estradiol; Etonogestrel
  • Ethinyl Estradiol; Levonorgestrel
  • Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate
  • Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
  • Ethinyl Estradiol; Norelgestromin
  • Ethinyl Estradiol; Norethindrone
  • Ethinyl Estradiol; Norethindrone Acetate
  • Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
  • Ethinyl Estradiol; Norethindrone; Ferrous fumarate
  • Ethinyl Estradiol; Norgestimate
  • Ethinyl Estradiol; Norgestrel
  • Fosphenytoin
  • Glimepiride
  • Glimepiride; Pioglitazone
  • Glimepiride; Rosiglitazone
  • Glipizide
  • Glipizide; Metformin
  • Glyburide
  • Glyburide; Metformin
  • Methylergonovine
  • Methysergide
  • Nystatin
  • Pergolide
  • Phenytoin
  • Progesterone
  • Segesterone Acetate; Ethinyl Estradiol
  • Sulfonylureas
  • Tolazamide
  • Tolbutamide
  • Torsemide
  • Warfarin

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