Micafungin Brand Name– Mycamine
What is Micafungin
Micafungin is an intravenous echinocandin antifungal agent, with antifungal activity against Candida albicans, C. glabrata, C. guilliermondii, C. krusei, C. parapsilosis, and C. tropicalis. Micafungin, a semisynthetic lipopeptide, is derived from a fermentation product of Coleophoma empetri.
It is approved for use in adults and pediatric patients 4 months and older to treat esophageal candidiasis, candidemia, acute disseminated candidiasis,
Candida peritonitis and abscesses, and for the prophylaxis of Candida infections in patients undergoing hematopoietic stem cell transplantation.
The drug is also approved for use in pediatric patients younger than 4 months of age to treat candidemia, acute disseminated candidiasis, Candida peritonitis and abscesses without meningoencephalitis or ocular dissemination; however, micafungin has been used off-label to treat CNS infections in these patients.
Indications
- aspergillosis
- aspergillosis prophylaxis
- bone and joint infections
- Candida albicans
- Candida glabrata
- Candida guilliermondii
- Candida krusei
- Candida parapsilosis
- Candida tropicalis
- candidemia
- candidiasis
- candidiasis prophylaxis
- endocarditis
- esophageal candidiasis
- febrile neutropenia
- infectious arthritis
- intraabdominal abscess
- intraabdominal infections
- oropharyngeal candidiasis (thrush)
- osteomyelitis
- peritonitis
- pneumonia
Side Effects
- abdominal pain
- anaphylactic shock
- anaphylactoid reactions
- anemia
- anxiety
- ascites
- atrial fibrillation
- azotemia
- cardiac arrest
- coagulopathy
- dehydration
- delirium
- diarrhea
- disseminated intravascular coagulation (DIC)
- dyspnea
- edema
- elevated hepatic enzymes
- encephalopathy
- epistaxis
- fever
- GI perforation
- headache
- hematuria
- hemolysis
- hemolytic anemia
- hepatic failure
- hepatitis
- hepatomegaly
- hyperbilirubinemia
- hyperglycemia
- hyperkalemia
- hypermagnesemia
- hypernatremia
- hypertension
- hypertonia
- hypocalcemia
- hypoglycemia
- hypokalemia
- hypotension
- ileus
- infusion-related reactions
- injection site reaction
- insomnia
- intracranial bleeding
- jaundice
- leukocytosis
- myocardial infarction
- nausea
- neutropenia
- oliguria
- pancytopenia
- pericardial effusion
- peripheral edema
- peripheral vasodilation
- phlebitis
- pleural effusion
- pruritus
- rash
- renal failure (unspecified)
- seizures
- sinus tachycardia
- Stevens-Johnson syndrome
- thrombocytopenia
- thrombocytosis
- thrombosis
- thrombotic thrombocytopenic purpura (TTP)
- toxic epidermal necrolysis
- urticaria
- vomiting
Monitoring Parameters
- CBC
- LFTs
- serum creatinine/BUN
Contraindications
- breast-feeding
- cholestasis
- hepatic disease
- hepatitis
- infants
- infusion-related reactions
- jaundice
- neonates
- pregnancy
- renal disease
- renal failure
- renal impairment
Interactions
- Corticosteroids
- Cyclosporine
- Dichlorphenamide
- Itraconazole
- Mycophenolate
- Nifedipine
- Saccharomyces boulardii
- Sirolimus
- Tacrolimus
